Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5376
Official Symbol:PMP22
Other Aliases:CMT1A|CMT1E|DSS|GAS-3|HNPP|MGC20769|Sp110
See related:HGNC:9118|MIM:601097|HPRD:03059
Chromosome:17
Location:17p12-p11.2
Gene Description:peripheral myelin protein 22
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0171
ORGANISM:human
Entrez Gene ID:5376
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15312160
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-
KARG Evidence 2
KARG ID:EVIM0287
ORGANISM:human
Entrez Gene ID:5376
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Downregulated
Fold Change:-0.56
KARG Evidence 3
KARG ID:EVIM0334
ORGANISM:human
Entrez Gene ID:5376
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.62
KARG Evidence 4
KARG ID:EVIM0824
ORGANISM:human
Entrez Gene ID:5376
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.5 :: -1.8 :: 1.4 :: 1
KARG Evidence 5
KARG ID:EVIM0825
ORGANISM:human
Entrez Gene ID:5376
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:3.3 :: 1.3
KARG Evidence 6
KARG ID:EVIM0826
ORGANISM:human
Entrez Gene ID:5376
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-5.7 :: -4.8
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18858CBCerebellum29.027825673421231.7235794067383
18858CTXCerebral cortex3.91295361518863.48058799902598
18858HIPHippocampal region3.611109634240474.5560194849968
18858HPFHippocampal formation4.147481262683874.54681966702143
18858HYHypothalamus8.684720675150556.84076070785522
18858LSXLateral septal complex2.516431550184891.95005010565122
18858MBMidbrain15.257078488667812.9188361167908
18858MYMedulla35.134681701660234.4642321268717
18858OLFOlfactory bulb11.39366292953499.60644714037577
18858PPons40.27144304911338.2987562815348
18858PALPallidum9.631837209065767.93048238754272
18858RHPRetrohippocampal region5.609889030456545.14915670951207
18858sAMYStriatum-like amygdalar nuclei5.096780300140384.15268778800964
18858STRStriatum7.333856821060185.87951147556305
18858STRdStriatum dorsal region9.325621922810877.70645785331726
18858STRvStriatum ventral region4.327773849169412.94272003571192
18858THThalamus16.655260721842414.7564148902893
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5376GO:0005624NRComponentmembrane fraction
5376GO:0005887NRComponentintegral to plasma membrane
5376GO:0007268TASProcesssynaptic transmission
5376GO:0007422TASProcessperipheral nervous system development
5376GO:0007605IEAProcesssensory perception of sound
5376GO:0007638IEAProcessmechanosensory behavior
5376GO:0008285NRProcessnegative regulation of cell proliferation
5376GO:0016020IEAComponentmembrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_000295.1--CNXHPRD03059
NP_000295.15824NP_002848.1peroxisomal biogenesis factor 19HPRD03059
NP_000295.15824NP_002848.1peroxisomal biogenesis factor 19HPRD02610
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5376PMP22_HUMANQ01453IPR006187ClaudinClaudin tight junction protein
5376PMP22_HUMANQ01453IPR003936PMP22Peripheral myelin protein PMP22
5376PMP22_HUMANQ01453IPR004031PMP22_ClaudinPMP-22/EMP/MP20 and claudin
5376PMP22_HUMANQ01453IPR004032PMP22_EMP_MP20PMP-22/EMP/MP20
5376PMP22_HUMANQ01453IPR008368VDCCGammaVoltage-dependent calcium channel gamma

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