Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:539
Official Symbol:ATP5O
Other Aliases:ATPO|OSCP
See related:HGNC:850|MIM:600828|HPRD:02899
Chromosome:21
Location:21q22.1-q22.2|21q22.11
Gene Description:ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0952
ORGANISM:human
Entrez Gene ID:539
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.5 :: 1.5
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
28080CBCerebellum60.4890289306641100.0
28080CTXCerebral cortex100.0100.0
28080HIPHippocampal region100.0100.0
28080HPFHippocampal formation100.0100.0
28080HYHypothalamus100.0100.0
28080LSXLateral septal complex100.0100.0
28080MBMidbrain100.0100.0
28080MYMedulla97.8036651611328100.0
28080OLFOlfactory bulb100.0100.0
28080PPons99.3220825195312100.0
28080PALPallidum100.0100.0
28080RHPRetrohippocampal region100.0100.0
28080sAMYStriatum-like amygdalar nuclei100.0100.0
28080STRStriatum100.0100.0
28080STRdStriatum dorsal region100.0100.0
28080STRvStriatum ventral region100.0100.0
28080THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
539GO:0005215NASFunctiontransporter activity
539GO:0005624NRComponentmembrane fraction
539GO:0005739IEAComponentmitochondrion
539GO:0005753TASComponentproton-transporting ATP synthase complex (sensu Eukaryota)
539GO:0006811IEAProcession transport
539GO:0015986IEAProcessATP synthesis coupled proton transport
539GO:0015992IEAProcessproton transport
539GO:0016469IEAComponentproton-transporting two-sector ATPase complex
539GO:0016787IEAFunctionhydrolase activity
539GO:0045261IEAComponentproton-transporting ATP synthase complex, catalytic core F(1)
539GO:0046872IEAFunctionmetal ion binding
539GO:0046933IEAFunctionhydrogen-transporting ATP synthase activity, rotational mechanism
539GO:0046961IEAFunctionhydrogen-transporting ATPase activity, rotational mechanism
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_001688.1---BIND262810
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
539ATPO_HUMANP48047IPR000711ATPase_F1_OSCP/dATPase, F1 complex, OSCP/delta subunit

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