Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5394
Official Symbol:EXOSC10
Other Aliases:PM-Scl|PM/Scl-100|PMSCL|PMSCL2|RRP6|Rrp6p|p2|p3|p4
See related:HGNC:9138|MIM:605960|HPRD:16180
Chromosome:1
Location:1p36.22
Gene Description:exosome component 10
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0225
ORGANISM:human
Entrez Gene ID:5394
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Upregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
50912CBCerebellum0.00.0
50912CTXCerebral cortex0.00.0
50912HIPHippocampal region0.00.0
50912HPFHippocampal formation0.00.0
50912HYHypothalamus0.00.0
50912LSXLateral septal complex0.00.0
50912MBMidbrain0.00.0
50912MYMedulla0.00.0
50912OLFOlfactory bulb0.00.0
50912PPons0.00.0
50912PALPallidum0.00.0
50912RHPRetrohippocampal region0.00.0
50912sAMYStriatum-like amygdalar nuclei0.00.0
50912STRStriatum0.00.0
50912STRdStriatum dorsal region0.00.0
50912STRvStriatum ventral region0.00.0
50912THThalamus0.00.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5394GO:0000184IEAProcessmRNA catabolism, nonsense-mediated decay
5394GO:0003723IEAFunctionRNA binding
5394GO:0004674TASFunctionprotein serine/threonine kinase activity
5394GO:0005634IEAComponentnucleus
5394GO:0005730TASComponentnucleolus
5394GO:0006364IEAProcessrRNA processing
5394GO:0008408IEAFunction3'-5' exonuclease activity
5394GO:0016787IEAFunctionhydrolase activity
5394GO:0042802IPIFunctionidentical protein binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-54512NP_061910.1exosome component 4HPRD16221
NP_001001998.151013-Exosomal core protein CSL4HPRD16180
NP_001001998.19020NP_003945.1mitogen-activated protein kinase kinase kinase 14HPRD16180
NP_001001998.110200NP_005783.1M-phase phosphoprotein 6HPRD16111
NP_001001998.110200NP_005783.1M-phase phosphoprotein 6HPRD16180
NP_001001998.110519NP_006375.1calcium and integrin binding 1 (calmyrin)HPRD16180
NP_001001998.110600NP_006438.1ubiquitin specific protease 16 isoform aHPRD16180
NP_001001998.122803NP_036387.25'-3' exoribonuclease 2HPRD10309
NP_001001998.122803NP_036387.25'-3' exoribonuclease 2HPRD16180
NP_001001998.151010NP_057126.2exosome component 3 isoform 1HPRD16180
NP_001001998.151010NP_057126.2exosome component 3 isoform 1HPRD16220
NP_001001998.151013NP_057130.1exosomal core protein CSL4HPRD16223
NP_001001998.154512NP_061910.1exosome component 4HPRD16180
NP_001001998.156915NP_064543.3exosome component Rrp46HPRD16180
NP_001001998.156915NP_064543.3exosome component Rrp46HPRD16222
NP_001001998.1118460NP_478126.1homolog of yeast mRNA transport regulator 3HPRD16180
NP_001001998.1118460NP_478126.1homolog of yeast mRNA transport regulator 3HPRD12107
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5394IPR0025623_5_exonuclease3'-5' exonuclease
5394IPR002121HRDCHRDC
5394IPR012588PMC2NTPMC2NT
5394EXOSX_HUMANQ01780IPR0025623_5_exonuclease3'-5' exonuclease
5394EXOSX_HUMANQ01780IPR002121HRDCHRDC
5394EXOSX_HUMANQ01780IPR012588PMC2NTPMC2NT

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