Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5414
Official Symbol:SEPT4
Other Aliases:ARTS|CE5B3|H5|PNUTL2|hCDCREL-2|hucep-7
See related:HGNC:9165|MIM:603696|HPRD:04738
Chromosome:17
Location:17q22-q23
Gene Description:septin 4
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0076
ORGANISM:human
Entrez Gene ID:5414
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.98 :: -0.08 :: -0.04 :: -0.78 :: -0.83 :: -0.49 :: -0.47 :: -0.02 :: -0.11 :: -0.94
KARG Evidence 2
KARG ID:EVIM0117
ORGANISM:human
Entrez Gene ID:5414
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:1.91 :: 1.53 :: 0.21 :: 0.83 :: -0.86 :: -2.28 :: -3.72
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18951CBCerebellum30.02728939056444.7450904846191
18951CTXCerebral cortex85.794231414794976.9787826538086
18951HIPHippocampal region57.774473190307671.8926315307617
18951HPFHippocampal formation56.188972473144564.5412921905518
18951HYHypothalamus17.460515975952112.3348612785339
18951LSXLateral septal complex10.57887363433848.22610688209534
18951MBMidbrain25.583589076995824.2012910842896
18951MYMedulla37.619247436523437.2249584197998
18951OLFOlfactory bulb75.760931015014679.3707904815674
18951PPons27.555954933166529.5373735427856
18951PALPallidum9.014754772186288.6018648147583
18951RHPRetrohippocampal region51.973136901855551.8849964141846
18951sAMYStriatum-like amygdalar nuclei38.856842041015631.0020017623901
18951STRStriatum28.942823410034221.4802894592285
18951STRdStriatum dorsal region26.546517372131319.9335279464722
18951STRvStriatum ventral region40.571244239807126.8821868896484
18951THThalamus44.739385604858445.341817855835
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5414GO:0000166IEAFunctionnucleotide binding
5414GO:0000910TASProcesscytokinesis
5414GO:0003924TASFunctionGTPase activity
5414GO:0005198TASFunctionstructural molecule activity
5414GO:0005525IEAFunctionGTP binding
5414GO:0005634NASComponentnucleus
5414GO:0005739NASComponentmitochondrion
5414GO:0007049IEAProcesscell cycle
5414GO:0042981NASProcessregulation of apoptosis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-9627NP_005451.1synuclein alpha interacting proteinHPRD04804
NP_004565.19627-Synphilin 1HPRD04738
NP_004565.123176AAH01329.1SEPT8 proteinHPRD12228
NP_004565.123176AAO13880.1septin SEPT8_v3BIND294883
NP_004565.16620NP_003076.1beta-synucleinHPRD03980
NP_004565.16620NP_003076.1beta-synucleinHPRD04738
NP_004565.15414NP_004565.1septin 4 isoform 1BIND294886
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5414IPR000038Cell_Div_GTP_bdCell division/GTP binding protein
5414SEPT4_HUMANO43236IPR000038Cell_Div_GTP_bdCell division/GTP binding protein

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