Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:54205
Official Symbol:CYCS
Other Aliases:CYC|HCS
See related:HGNC:19986|MIM:123970|HPRD:00479
Chromosome:7
Location:7p15.2
Gene Description:cytochrome c, somatic
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0096
ORGANISM:human
Entrez Gene ID:54205
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:3.33 :: 3.50 :: 5.40 :: 2.45 :: -3.82 :: -3.19 :: -0.96
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
54205GO:0005506IEAFunctioniron ion binding
54205GO:0005515IPIFunctionprotein binding
54205GO:0005739IEAComponentmitochondrion
54205GO:0005746IEAComponentmitochondrial electron transport chain
54205GO:0005758ISSComponentmitochondrial intermembrane space
54205GO:0005758TASComponentmitochondrial intermembrane space
54205GO:0005829IMPComponentcytosol
54205GO:0005829ISSComponentcytosol
54205GO:0006118IEAProcesselectron transport
54205GO:0006309IMPProcessDNA fragmentation during apoptosis
54205GO:0006309ISSProcessDNA fragmentation during apoptosis
54205GO:0006915IDAProcessapoptosis
54205GO:0008635ISSProcesscaspase activation via cytochrome c
54205GO:0008635TASProcesscaspase activation via cytochrome c
54205GO:0020037TASFunctionheme binding
54205GO:0045155IDAFunctionelectron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity
54205GO:0045155ISSFunctionelectron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity
54205GO:0045333ISSProcesscellular respiration
54205GO:0045333TASProcesscellular respiration
54205GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-84701NP_115998.2cytochrome c oxidase subunit IV isoform 2HPRD12143
NP_061820.1--Cytochrome C peroxidaseHPRD00479
NP_061820.1--Cytochrome C oxidaseHPRD00479
NP_061820.1--Cytochrome B5HPRD00479
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
54205CYC_HUMANP99999IPR003088Cyt_CICytochrome c, class I
54205CYC_HUMANP99999IPR002327Cyt_CIABCytochrome c, class IA/ IB

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