Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5425
Official Symbol:POLD2
Other Aliases:-
See related:HGNC:9176|MIM:600815|HPRD:15982
Chromosome:7
Location:7p13
Gene Description:polymerase (DNA directed), delta 2, regulatory subunit 50kDa
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0245
ORGANISM:human
Entrez Gene ID:5425
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Upregulated
Fold Change:0.60
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18972CBCerebellum1.038259744644171.54031252861023
18972CTXCerebral cortex1.676408648490911.96582913398743
18972HIPHippocampal region1.246181130409242.26623296737671
18972HPFHippocampal formation1.074765682220461.66957366466522
18972HYHypothalamus2.00789809226994.40706205368042
18972LSXLateral septal complex0.0971055477857590.0
18972MBMidbrain0.8514859676361082.08447170257568
18972MYMedulla0.8484900593757631.22668302059174
18972OLFOlfactory bulb4.102744102478034.21985197067261
18972PPons2.619366407394416.89546203613281
18972PALPallidum0.665316283702851.27043187618256
18972RHPRetrohippocampal region0.4907898902893070.485886096954346
18972sAMYStriatum-like amygdalar nuclei1.604252219200132.95591688156128
18972STRStriatum0.676147341728210.880908787250519
18972STRdStriatum dorsal region0.2779743969440460.344170659780502
18972STRvStriatum ventral region1.709079623222351.69265818595886
18972THThalamus0.2664267122745510.425242036581039
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5425GO:0003677IEAFunctionDNA binding
5425GO:0003887IEAFunctionDNA-directed DNA polymerase activity
5425GO:0005515IPIFunctionprotein binding
5425GO:0005634TASComponentnucleus
5425GO:0006260TASProcessDNA replication
5425GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-10714NP_006582.1polymerase (DNA directed), delta 3HPRD11446
NP_006221.110714-DNA polymerase delta subunit 3HPRD15982
NP_006221.126073NP_056399.1DNA polymerase delta interacting protein 2HPRD17874
NP_006221.126073NP_056399.1DNA polymerase delta interacting protein 2HPRD15982
NP_006221.126073NP_056399.1DNA polymerase delta interacting protein 2BIND144549
NP_006221.184271NP_115687.2DNA polymerase delta interacting protein 3 isoform 1HPRD17875
NP_006221.184271NP_115687.2DNA polymerase delta interacting protein 3 isoform 1HPRD15982
NP_006221.184271NP_115687.2DNA polymerase delta interacting protein 3 isoform 1BIND144548
NP_006221.1253980NP_849194.1potassium channel tetramerisation domain containing 13HPRD15982
NP_006221.1253980NP_849194.1potassium channel tetramerisation domain containing 13HPRD12339
NP_006221.1253980NP_849194.1potassium channel tetramerisation domain containing 13BIND145574
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5425DPOD2_HUMANP49005IPR007185DNA_pol_E_BDNA polymerase epsilon subunit B
5425DPOD2_HUMANP49005IPR000565Topo_IIA_BDNA topoisomerase, type IIA, subunit B

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