Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:54704
Official Symbol:PPM2C
Other Aliases:FLJ32517|MGC119646|PDH|PDP|PDP1
See related:HGNC:9279|MIM:605993|HPRD:16185
Chromosome:8
Location:8q22.1
Gene Description:protein phosphatase 2C, magnesium-dependent, catalytic subunit
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0598
ORGANISM:human
Entrez Gene ID:54704
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:54705
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0319
ORGANISM:human
Entrez Gene ID:54704
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.51
KARG Evidence 3
KARG ID:HOT0061
ORGANISM:human
Entrez Gene ID:54704
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
381511CBCerebellum24.588518142700229.9670743942261
381511CTXCerebral cortex100.0100.0
381511HIPHippocampal region28.538052558898943.8933753967285
381511HPFHippocampal formation36.584936141967842.8564281463623
381511HYHypothalamus36.913226127624526.0377388000488
381511LSXLateral septal complex77.376499176025468.8614292144775
381511MBMidbrain39.449567794799835.2962760925293
381511MYMedulla38.565769195556643.2859554290771
381511OLFOlfactory bulb69.726360321044987.4775199890137
381511PPons40.727114677429241.2822914123535
381511PALPallidum40.901094913482732.3142213821411
381511RHPRetrohippocampal region47.114692687988341.2567729949951
381511sAMYStriatum-like amygdalar nuclei47.089276313781731.6601486206055
381511STRStriatum100.0100.0
381511STRdStriatum dorsal region100.0100.0
381511STRvStriatum ventral region91.393608093261795.5437469482422
381511THThalamus100.0100.0
KARG Evidence 4
KARG ID:HOT0061
Entrez Gene ID:54704
RefSeq ID:NM_018444
Position Information:+, _3UTR, 0bp
Linkage Marker:rs911
Evidence Type:ASSOCIATION GENOME SCANNING
Evidence Name:PUBMED
Evidence ID:11704927
Addiction Drug:POLYSUBSTANCE
Addiction Drug Detail:POLYSUBSTANCE ABUSE
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
54704GO:0000287IEAFunctionmagnesium ion binding
54704GO:0004722IEAFunctionprotein serine/threonine phosphatase activity
54704GO:0004741IEAFunction[pyruvate dehydrogenase (lipoamide)] phosphatase activity
54704GO:0005509IEAFunctioncalcium ion binding
54704GO:0005739IEAComponentmitochondrion
54704GO:0006470IEAProcessprotein amino acid dephosphorylation
54704GO:0008287IEAComponentprotein serine/threonine phosphatase complex
54704GO:0016787IEAFunctionhydrolase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
54704PDP1_HUMANQ9P0J1IPR000222PP2CProtein phosphatase 2C
54704PDP1_HUMANQ9P0J1IPR001932PP2C-likeProtein phosphatase 2C-like

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