Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5495
Official Symbol:PPM1B
Other Aliases:MGC21657|PP2C-beta-X|PP2CB|PP2CBETA|PPC2BETAX
See related:HGNC:9276|MIM:603770|HPRD:04796
Chromosome:2
Location:2p21
Gene Description:protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0253
ORGANISM:human
Entrez Gene ID:5495
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:19043
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
19043CBCerebellum36.74676895141681.2131576538086
19043CTXCerebral cortex48.629028320312541.8620872497559
19043HIPHippocampal region27.061550140380930.6748867034912
19043HPFHippocampal formation28.919799804687529.3009471893311
19043HYHypothalamus7.569269657135016.39529180526733
19043LSXLateral septal complex2.892252683639532.40607500076294
19043MBMidbrain17.541189193725618.5870170593262
19043MYMedulla19.492040634155327.0137996673584
19043OLFOlfactory bulb26.227210998535223.8377857208252
19043PPons19.764413833618223.698392868042
19043PALPallidum12.032988548278813.6559324264526
19043RHPRetrohippocampal region33.705619812011728.7335605621338
19043sAMYStriatum-like amygdalar nuclei12.80365657806411.4627933502197
19043STRStriatum12.01684665679939.89509010314941
19043STRdStriatum dorsal region11.86676406860359.49539470672607
19043STRvStriatum ventral region16.369707107543913.297456741333
19043THThalamus43.694591522216842.1275749206543
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5495GO:0000287IEAFunctionmagnesium ion binding
5495GO:0006470TASProcessprotein amino acid dephosphorylation
5495GO:0008287IEAComponentprotein serine/threonine phosphatase complex
5495GO:0015071TASFunctionprotein phosphatase type 2C activity
5495GO:0016787IEAFunctionhydrolase activity
5495GO:0030145IEAFunctionmanganese ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6885NP_663304.1mitogen-activated protein kinase kinase kinase 7 isoform BHPRD04011
NP_002697.16885-MAP3K7HPRD04796
NP_002697.18517NP_003630.1inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gammaHPRD02217
NP_002697.18517NP_003630.1inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gammaHPRD04796
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5495IPR000222PP2CProtein phosphatase 2C
5495IPR001932PP2C-likeProtein phosphatase 2C-like
5495IPR012911PP2C_CProtein serine/threonine phosphatase 2C, C-terminal
5495PP2CB_HUMANO75688IPR000222PP2CProtein phosphatase 2C
5495PP2CB_HUMANO75688IPR001932PP2C-likeProtein phosphatase 2C-like
5495PP2CB_HUMANO75688IPR012911PP2C_CProtein serine/threonine phosphatase 2C, C-terminal

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