Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5499
Official Symbol:PPP1CA
Other Aliases:MGC15877|MGC1674|PP-1A|PPP1A
See related:HGNC:9281|MIM:176875|HPRD:15942
Chromosome:11
Location:11q13
Gene Description:protein phosphatase 1, catalytic subunit, alpha isoform
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0144
ORGANISM:human
Entrez Gene ID:5499
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:1.75 :: 1.25 :: -0.71 :: 0.38 :: -1.52 :: -1.80 :: -1.25
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
19045CBCerebellum23.711484909057629.0984134674072
19045CTXCerebral cortex69.158493041992257.2002487182617
19045HIPHippocampal region39.85261154174859.5522880554199
19045HPFHippocampal formation40.621986389160250.5218505859375
19045HYHypothalamus9.997056007385257.97844791412354
19045LSXLateral septal complex18.627174377441414.1343965530396
19045MBMidbrain8.783668518066419.15260696411133
19045MYMedulla14.712713241577116.5441761016846
19045OLFOlfactory bulb49.226585388183652.4985389709473
19045PPons13.943596839904816.3679637908936
19045PALPallidum18.856824874877919.5949306488037
19045RHPRetrohippocampal region41.656429290771537.5510597229004
19045sAMYStriatum-like amygdalar nuclei29.709474563598623.4240474700928
19045STRStriatum89.03380584716879.5440368652344
19045STRdStriatum dorsal region100.0100.0
19045STRvStriatum ventral region62.325126647949253.3374519348145
19045THThalamus15.044290542602513.9402437210083
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5499GO:0004721IEAFunctionphosphoprotein phosphatase activity
5499GO:0005506IEAFunctioniron ion binding
5499GO:0005975IEAProcesscarbohydrate metabolism
5499GO:0005977IEAProcessglycogen metabolism
5499GO:0007049IEAProcesscell cycle
5499GO:0016787IEAFunctionhydrolase activity
5499GO:0030145IEAFunctionmanganese ion binding
5499GO:0046872IEAFunctionmetal ion binding
5499GO:0051301IEAProcesscell division
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-55607BAA90928.1unnamed protein productHPRD16000
-23026BAC87143.1unnamed protein productHPRD14795
-7048NP_003233.3transforming growth factor, beta receptor IIBIND217947
-7046NP_004603.1transforming growth factor, beta receptor I precursorBIND217946
NP_001008709.155607-Protein phosphotase 1, regulatory subunit 9AHPRD15942
NP_001008709.15504-Protein phosphatase inhibitor 2HPRD15942
NP_001008709.16790-Serine/threonine protein kinase 6HPRD15942
NP_001008709.123026-Myosin heavy chain Myr 8HPRD15942
NP_001008709.15610NP_002750.1eukaryotic translation initiation factor 2-alpha kinase 2HPRD15942
NP_001008709.18165NP_003479.1A-kinase anchor protein 1 isoform 1 precursorHPRD15942
NP_001008709.1116154NP_542403.1phosphatase and actin regulator 3 isoform 1HPRD10571
NP_001008709.1116154NP_542403.1phosphatase and actin regulator 3 isoform 1HPRD15942
NP_001008709.110142NP_671700.1A-kinase anchor protein 9 isoform 1HPRD15942
NP_002699.1155871NP_057853.1Tat--
NP_002699.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5499IPR004843M-pesteraseMetallophosphoesterase
5499IPR013622Metallophos_CCalcineurin-like phosphoesterase C-terminal
5499IPR006186T_phtase_apaHSerine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase
5499PP1A_HUMANP62136IPR004843M-pesteraseMetallophosphoesterase
5499PP1A_HUMANP62136IPR013622Metallophos_CCalcineurin-like phosphoesterase C-terminal
5499PP1A_HUMANP62136IPR006186T_phtase_apaHSerine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase

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