Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5504
Official Symbol:PPP1R2
Other Aliases:IPP2|MGC87148
See related:HGNC:9288|MIM:601792|HPRD:03478
Chromosome:3
Location:3q29
Gene Description:protein phosphatase 1, regulatory (inhibitor) subunit 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0346
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:66849
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:HOT0200
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:HOT0167
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 4
KARG ID:HOT0234
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 5
KARG ID:HOT0047
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 6
KARG ID:HOT0044
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 7
KARG ID:HOT0048
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 8
KARG ID:HOT0199
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 9
KARG ID:HOT0174
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 10
KARG ID:HOT0196
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 11
KARG ID:HOT0046
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 12
KARG ID:HOT0018
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 13
KARG ID:HOT0049
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 14
KARG ID:HOT0201
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 15
KARG ID:HOT0307
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 16
KARG ID:HOT0306
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 17
KARG ID:HOT0289
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 18
KARG ID:HOT0202
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 19
KARG ID:HOT0045
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 20
KARG ID:HOT0235
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 21
KARG ID:HOT0233
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 22
KARG ID:HOT0173
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 23
KARG ID:HOT0166
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 24
KARG ID:HOT0318
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 25
KARG ID:HOT0262
ORGANISM:human
Entrez Gene ID:5504
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
66849CBCerebellum24.48927593231241.317985534668
76705CBCerebellum4.236349105834964.93540048599243
76705CTXCerebral cortex2.001837730407712.07089018821716
66849CTXCerebral cortex48.465251922607441.4898090362549
76705HIPHippocampal region1.061346173286441.04667925834656
66849HIPHippocampal region39.291471481323270.1890602111816
76705HPFHippocampal formation2.412699460983282.30983591079712
66849HPFHippocampal formation44.149639129638763.1979427337646
76705HYHypothalamus0.264467328786850.262164503335953
66849HYHypothalamus9.399374723434458.2875189781189
76705LSXLateral septal complex0.6836913824081420.75604248046875
66849LSXLateral septal complex29.957289695739731.7050561904907
76705MBMidbrain0.3800567090511320.455778539180756
66849MBMidbrain15.462710857391416.0032997131348
76705MYMedulla1.735635757446291.86328172683716
66849MYMedulla26.12928295135535.7451601028442
76705OLFOlfactory bulb2.460864782333372.95893216133118
66849OLFOlfactory bulb57.904233932495169.0459995269775
76705PPons0.2079277336597440.25140517950058
66849PPons21.176764965057426.9875936508179
76705PALPallidum0.8591161966323850.935782670974731
66849PALPallidum28.263259887695333.3626832962036
76705RHPRetrohippocampal region5.017560482025154.32495594024658
66849RHPRetrohippocampal region52.031318664550854.6744651794434
76705sAMYStriatum-like amygdalar nuclei0.2174342125654220.199939772486687
66849sAMYStriatum-like amygdalar nuclei27.269540786743226.4007062911987
76705STRStriatum0.5279982089996340.581805169582367
66849STRStriatum88.411884307861392.0356292724609
76705STRdStriatum dorsal region0.502548754215240.589154124259949
66849STRdStriatum dorsal region84.150234222412186.2410774230957
76705STRvStriatum ventral region0.7253295779228210.698419213294983
66849STRvStriatum ventral region100.0100.0
76705THThalamus0.4505006968975070.658936619758606
66849THThalamus26.086421966552724.4349889755249
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5504GO:0004865TASFunctiontype 1 serine/threonine specific protein phosphatase inhibitor activity
5504GO:0005515IPIFunctionprotein binding
5504GO:0005975IEAProcesscarbohydrate metabolism
5504GO:0005977IEAProcessglycogen metabolism
5504GO:0006091TASProcessgeneration of precursor metabolites and energy
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-22853NP_055731.2lemur tyrosine kinase 2HPRD13994
-84687NP_115984.1protein phosphatase 1, regulatory subunit 9BHPRD04506
NP_006232.1--PPP1CAHPRD03478
NP_006232.1--PPP1CCHPRD03478
NP_006232.1--Neurabin IHPRD03478
NP_006232.184687-PPP1R9BHPRD03478
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5504IPP2_HUMANP41236IPR007062IPP-2Protein phosphatase inhibitor 2 (IPP-2)

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