Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5515
Official Symbol:PPP2CA
Other Aliases:PP2Ac|PP2CA|RP-C
See related:HGNC:9299|MIM:176915|HPRD:08912
Chromosome:5
Location:5q31.1
Gene Description:protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0145
ORGANISM:human
Entrez Gene ID:5515
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:1.32 :: 1.10 :: 2.08 :: 2.34 :: -1.73 :: -1.59 :: -1.06
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
19052CBCerebellum36.101147651672470.9215831756592
19052CTXCerebral cortex93.433399200439599.572639465332
19052HIPHippocampal region85.2692413330078100.0
19052HPFHippocampal formation88.8671188354492100.0
19052HYHypothalamus69.323726654052770.6568183898926
19052LSXLateral septal complex67.619821548461968.2664413452148
19052MBMidbrain61.694627761840864.7892980575562
19052MYMedulla65.265130996704178.7216415405273
19052OLFOlfactory bulb81.971801757812598.0373344421387
19052PPons66.65314865112376.9660377502441
19052PALPallidum70.344919204711976.5369777679443
19052RHPRetrohippocampal region100.0100.0
19052sAMYStriatum-like amygdalar nuclei86.01110076904389.3566246032715
19052STRStriatum77.529108047485476.8791599273682
19052STRdStriatum dorsal region75.184946060180773.288143157959
19052STRvStriatum ventral region87.433158874511786.624755859375
19052THThalamus69.475156784057673.9993686676025
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5515GO:0000074NASProcessregulation of progression through cell cycle
5515GO:0000074TASProcessregulation of progression through cell cycle
5515GO:0000159TASComponentprotein phosphatase type 2A complex
5515GO:0000188NASProcessinactivation of MAPK activity
5515GO:0004721IEAFunctionphosphoprotein phosphatase activity
5515GO:0005506IEAFunctioniron ion binding
5515GO:0005625NASComponentsoluble fraction
5515GO:0005634NASComponentnucleus
5515GO:0005739NASComponentmitochondrion
5515GO:0005829TASComponentcytosol
5515GO:0006275NASProcessregulation of DNA replication
5515GO:0006445NASProcessregulation of translation
5515GO:0006470TASProcessprotein amino acid dephosphorylation
5515GO:0006672NASProcessceramide metabolism
5515GO:0006917TASProcessinduction of apoptosis
5515GO:0008380NASProcessRNA splicing
5515GO:0010033NASProcessresponse to organic substance
5515GO:0015630NASComponentmicrotubule cytoskeleton
5515GO:0016020NASComponentmembrane
5515GO:0016787IEAFunctionhydrolase activity
5515GO:0019932NASProcesssecond-messenger-mediated signaling
5515GO:0030111NASProcessregulation of Wnt receptor signaling pathway
5515GO:0030145IEAFunctionmanganese ion binding
5515GO:0030155NASProcessregulation of cell adhesion
5515GO:0030308NASProcessnegative regulation of cell growth
5515GO:0040008NASProcessregulation of growth
5515GO:0042518NASProcessnegative regulation of tyrosine phosphorylation of Stat3 protein
5515GO:0045449NASProcessregulation of transcription
5515GO:0045595NASProcessregulation of cell differentiation
5515GO:0046872IEAFunctionmetal ion binding
5515GO:0046982IPIFunctionprotein heterodimerization activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5520NP_002708.1alpha isoform of regulatory subunit B55, protein phosphatase 2HPRD09223
-6198NP_003152.1ribosomal protein S6 kinase, 70kDa, polypeptide 1HPRD10202
NP_002706.1--PPP1CAHPRD08912
NP_002706.15520-Protein phosphatase 2 regulatory subunit B alphaHPRD08912
NP_002706.17157NP_000537.2tumor protein p53BIND13127
NP_002706.15519NP_002707.3beta isoform of regulatory subunit A, protein phosphatase 2 isoform aBIND146496
NP_002706.16801NP_003153.2striatin, calmodulin binding proteinHPRD18124
NP_002706.15518NP_055040.2alpha isoform of regulatory subunit A, protein phosphatase 2BIND149015
NP_002706.1155807NP_057852.2Vpr--
NP_002706.1155807NP_057852.2Vpr--
NP_002706.1155807NP_057852.2Vpr--
NP_002706.1155871NP_057853.1Tat--
NP_002706.1155030NP_579881.1nucleocapsid--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5515PP2AA_HUMANP67775IPR004843M-pesteraseMetallophosphoesterase
5515PP2AA_HUMANP67775IPR013622Metallophos_CCalcineurin-like phosphoesterase C-terminal
5515PP2AA_HUMANP67775IPR006186T_phtase_apaHSerine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase

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