Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5516
Official Symbol:PPP2CB
Other Aliases:PP2CB
See related:HGNC:9300|MIM:176916|HPRD:01487
Chromosome:8
Location:8p12
Gene Description:protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0223
ORGANISM:human
Entrez Gene ID:5516
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:19053
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0141
ORGANISM:human
Entrez Gene ID:5516
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:2.10 :: 2.50 :: 2.58 :: 1.69 :: -2.58 :: -2.32 :: -0.38
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
19053CBCerebellum33.199497222900452.5361785888672
19053CTXCerebral cortex100.0100.0
19053HIPHippocampal region56.819801330566492.9520416259766
19053HPFHippocampal formation74.561126708984495.4036712646484
19053HYHypothalamus53.967430114746149.4635543823242
19053LSXLateral septal complex66.418609619140654.8655204772949
19053MBMidbrain59.215869903564559.6603927612305
19053MYMedulla62.663742065429774.4221878051758
19053OLFOlfactory bulb89.697196960449282.8545989990234
19053PPons53.631584167480562.2320175170898
19053PALPallidum53.02813339233452.1489906311035
19053RHPRetrohippocampal region100.0100.0
19053sAMYStriatum-like amygdalar nuclei76.463874816894565.8796539306641
19053STRStriatum58.760292053222747.549674987793
19053STRdStriatum dorsal region55.434551239013745.5107307434082
19053STRvStriatum ventral region58.706230163574242.375904083252
19053THThalamus80.353744506835989.0441131591797
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5516GO:0000158TASFunctionprotein phosphatase type 2A activity
5516GO:0000159TASComponentprotein phosphatase type 2A complex
5516GO:0004721IEAFunctionphosphoprotein phosphatase activity
5516GO:0005506IEAFunctioniron ion binding
5516GO:0006470TASProcessprotein amino acid dephosphorylation
5516GO:0016787IEAFunctionhydrolase activity
5516GO:0030145IEAFunctionmanganese ion binding
5516GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_004147.1155807NP_057852.2Vpr--
NP_004147.1155807NP_057852.2Vpr--
NP_004147.1155807NP_057852.2Vpr--
NP_004147.1155871NP_057853.1Tat--
NP_004147.1155030NP_579881.1nucleocapsid--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5516PP2AB_HUMANP62714IPR004843M-pesteraseMetallophosphoesterase
5516PP2AB_HUMANP62714IPR013622Metallophos_CCalcineurin-like phosphoesterase C-terminal
5516PP2AB_HUMANP62714IPR006186T_phtase_apaHSerine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.