Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5522
Official Symbol:PPP2R2C
Other Aliases:IMYPNO|IMYPNO1|MGC33570|PR52
See related:HGNC:9306|MIM:605997|HPRD:09345
Chromosome:4
Location:4p16.1
Gene Description:protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0055
ORGANISM:human
Entrez Gene ID:5522
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-1.21 :: -0.23 :: 0.58 :: -0.23 :: -0.32 :: -0.46 :: -0.57 :: -0.48 :: 0.07 :: -0.87
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
269643CBCerebellum100.0100.0
269643CTXCerebral cortex100.0100.0
269643HIPHippocampal region100.0100.0
269643HPFHippocampal formation100.0100.0
269643HYHypothalamus100.093.9067153930664
269643LSXLateral septal complex100.0100.0
269643MBMidbrain100.0100.0
269643MYMedulla100.0100.0
269643OLFOlfactory bulb100.0100.0
269643PPons98.5702247619629100.0
269643PALPallidum100.098.1683349609375
269643RHPRetrohippocampal region100.0100.0
269643sAMYStriatum-like amygdalar nuclei100.0100.0
269643STRStriatum100.0100.0
269643STRdStriatum dorsal region100.0100.0
269643STRvStriatum ventral region100.0100.0
269643THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5522GO:0000159IEAComponentprotein phosphatase type 2A complex
5522GO:0000159NASComponentprotein phosphatase type 2A complex
5522GO:0007165IEAProcesssignal transduction
5522GO:0007165NASProcesssignal transduction
5522GO:0008601IEAFunctionprotein phosphatase type 2A regulator activity
5522GO:0008601NASFunctionprotein phosphatase type 2A regulator activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_065149.25894NP_002871.1v-raf-1 murine leukemia viral oncogene homolog 1BIND312506
NP_065149.2155807NP_057852.2Vpr--
NP_065149.2155807NP_057852.2Vpr--
NP_065149.2155807NP_057852.2Vpr--
NP_065149.2155871NP_057853.1Tat--
NP_065149.2155030NP_579881.1nucleocapsid--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5522IPR013577LLGL2Lethal giant larvae homologue 2
5522IPR000009Pp2A_PR55Protein phosphatase 2A regulatory subunit PR55
5522IPR001680WD40WD-40 repeat
55222ABG_HUMANQ9Y2T4IPR013577LLGL2Lethal giant larvae homologue 2
55222ABG_HUMANQ9Y2T4IPR000009Pp2A_PR55Protein phosphatase 2A regulatory subunit PR55
55222ABG_HUMANQ9Y2T4IPR001680WD40WD-40 repeat

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