Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5524
Official Symbol:PPP2R4
Other Aliases:MGC2184|PP2A|PR53|PTPA
See related:HGNC:9308|MIM:600756|HPRD:02858
Chromosome:9
Location:9q34
Gene Description:protein phosphatase 2A, regulatory subunit B' (PR 53)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0961
ORGANISM:human
Entrez Gene ID:5524
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.2 :: 1.1 :: 2.1 :: 2.5
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
110854CBCerebellum78.31713867187596.7705078125
110854CTXCerebral cortex100.0100.0
110854HIPHippocampal region73.383415222168100.0
110854HPFHippocampal formation100.0100.0
110854HYHypothalamus100.0100.0
110854LSXLateral septal complex100.0100.0
110854MBMidbrain100.0100.0
110854MYMedulla100.0100.0
110854OLFOlfactory bulb100.0100.0
110854PPons100.0100.0
110854PALPallidum100.0100.0
110854RHPRetrohippocampal region100.0100.0
110854sAMYStriatum-like amygdalar nuclei100.0100.0
110854STRStriatum100.087.9239654541016
110854STRdStriatum dorsal region93.470420837402373.2612152099609
110854STRvStriatum ventral region100.093.6637496948242
110854THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5524GO:0000159TASComponentprotein phosphatase type 2A complex
5524GO:0005625TASComponentsoluble fraction
5524GO:0006470NASProcessprotein amino acid dephosphorylation
5524GO:0008160TASFunctionprotein tyrosine phosphatase activator activity
5524GO:0008601NASFunctionprotein phosphatase type 2A regulator activity
5524GO:0019211IEAFunctionphosphatase activator activity
5524GO:0046982TASFunctionprotein heterodimerization activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_066954.1155030NP_579881.1nucleocapsid--
NP_066954.2155807NP_057852.2Vpr--
NP_066954.2155807NP_057852.2Vpr--
NP_066954.2155807NP_057852.2Vpr--
NP_066954.2155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5524IPR004327Phstyr_phstse_acPhosphotyrosyl phosphatase activator, PTPA
5524PTPA_HUMANQ15257IPR004327Phstyr_phstse_acPhosphotyrosyl phosphatase activator, PTPA

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