Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5530
Official Symbol:PPP3CA
Other Aliases:CALN|CALNA|CALNA1|CCN1|CNA1|PPP2B
See related:HGNC:9314|MIM:114105|HPRD:00234
Chromosome:4
Location:4q21-q24
Gene Description:protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:HOT0006
ORGANISM:human
Entrez Gene ID:5530
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
19055CBCerebellum99.4210014343262100.0
19055CTXCerebral cortex100.0100.0
19055HIPHippocampal region100.0100.0
19055HPFHippocampal formation100.0100.0
19055HYHypothalamus44.446571350097746.4363899230957
19055LSXLateral septal complex100.0100.0
19055MBMidbrain54.621982574462962.147144317627
19055MYMedulla53.508945465087974.8253517150879
19055OLFOlfactory bulb100.0100.0
19055PPons44.345067977905357.6736621856689
19055PALPallidum46.074575424194360.4140377044678
19055RHPRetrohippocampal region100.0100.0
19055sAMYStriatum-like amygdalar nuclei100.0100.0
19055STRStriatum100.0100.0
19055STRdStriatum dorsal region100.0100.0
19055STRvStriatum ventral region100.0100.0
19055THThalamus70.890581130981484.2588157653809
KARG Evidence 2
KARG ID:HOT0006
Entrez Gene ID:5530
RefSeq ID:NM_000944
Position Information:-, Intron, 0bp
Linkage Marker:rs1395475
Evidence Type:ASSOCIATION GENOME SCANNING
Evidence Name:PUBMED
Evidence ID:16091475
Addiction Drug:POLYSUBSTANCE
Addiction Drug Detail:POLYSUBSTANCE ABUSE
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5530GO:0004722NASFunctionprotein serine/threonine phosphatase activity
5530GO:0005506IEAFunctioniron ion binding
5530GO:0005509NASFunctioncalcium ion binding
5530GO:0005516NASFunctioncalmodulin binding
5530GO:0005634IEAComponentnucleus
5530GO:0005955NASComponentcalcineurin complex
5530GO:0006470NASProcessprotein amino acid dephosphorylation
5530GO:0008270IEAFunctionzinc ion binding
5530GO:0016787IEAFunctionhydrolase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6647CAA26182.1unnamed protein productHPRD00937
-9495NP_004848.2A-kinase anchor protein 5HPRD05255
-23523NP_036427.1calcineurin binding protein 1HPRD10369
NP_000935.1--Cabin1HPRD00234
NP_000935.19495-A kinase anchor protein 5HPRD00234
NP_000935.16647-SOD1HPRD00234
NP_000935.15590NP_002735.2protein kinase C, zetaHPRD00234
NP_000935.123770NP_036313.2FK506-binding protein 8HPRD00234
NP_000935.123770NP_036313.2FK506-binding protein 8HPRD05327
NP_000935.151778NP_057683.1myozenin 2HPRD00234
NP_000935.151778NP_057683.1myozenin 2HPRD05724
NP_000935.191977NP_588612.1myozenin 3HPRD17624
NP_000935.1200186NP_859066.1transducer of regulated cAMP response element-binding protein (CREB) 2BIND181864
NP_000935.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5530PP2BA_HUMANQ08209IPR004843M-pesteraseMetallophosphoesterase
5530PP2BA_HUMANQ08209IPR013622Metallophos_CCalcineurin-like phosphoesterase C-terminal
5530PP2BA_HUMANQ08209IPR006186T_phtase_apaHSerine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase

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