Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5532
Official Symbol:PPP3CB
Other Aliases:CALNA2|CALNB
See related:HGNC:9315|MIM:114106
Chromosome:10
Location:10q21-q22
Gene Description:protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0958
ORGANISM:human
Entrez Gene ID:5532
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.2 :: 1.3 :: 2.4 :: 2.5
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
19056CBCerebellum45.170558929443477.0341033935547
19056CTXCerebral cortex100.0100.0
19056HIPHippocampal region100.0100.0
19056HPFHippocampal formation100.0100.0
19056HYHypothalamus61.915309906005955.1135597229004
19056LSXLateral septal complex100.0100.0
19056MBMidbrain57.892730712890659.9736595153809
19056MYMedulla42.438655853271550.9776191711426
19056OLFOlfactory bulb100.0100.0
19056PPons47.627178192138758.6396980285645
19056PALPallidum70.856094360351671.8779830932617
19056RHPRetrohippocampal region100.0100.0
19056sAMYStriatum-like amygdalar nuclei100.0100.0
19056STRStriatum100.0100.0
19056STRdStriatum dorsal region100.0100.0
19056STRvStriatum ventral region100.0100.0
19056THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5532GO:0000074NASProcessregulation of progression through cell cycle
5532GO:0004722NASFunctionprotein serine/threonine phosphatase activity
5532GO:0005506IEAFunctioniron ion binding
5532GO:0005509IDAFunctioncalcium ion binding
5532GO:0005516NASFunctioncalmodulin binding
5532GO:0005955IDAComponentcalcineurin complex
5532GO:0006351NRProcesstranscription, DNA-dependent
5532GO:0006470NRProcessprotein amino acid dephosphorylation
5532GO:0007165NASProcesssignal transduction
5532GO:0008270IEAFunctionzinc ion binding
5532GO:0016787IEAFunctionhydrolase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-51778NP_057683.1myozenin 2HPRD05724
AAH28049.1--Cabin1HPRD00235
AAH28049.1--Calsarcin-3HPRD00235
AAH28049.151778-Myozenin 2HPRD00235
AAH28049.19021NP_003946.2suppressor of cytokine signaling 3HPRD00235
AAH28049.19021NP_003946.2suppressor of cytokine signaling 3HPRD05006
AAH28049.123523NP_036427.1calcineurin binding protein 1HPRD10369
AAH28049.123523NP_036427.1calcineurin binding protein 1HPRD10369
AAH28049.191977NP_588612.1myozenin 3HPRD17624
NP_066955.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5532PP2BB_HUMANP16298IPR004843M-pesteraseMetallophosphoesterase
5532PP2BB_HUMANP16298IPR013622Metallophos_CCalcineurin-like phosphoesterase C-terminal
5532PP2BB_HUMANP16298IPR000694PRO_richProline-rich region
5532PP2BB_HUMANP16298IPR006186T_phtase_apaHSerine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase

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