Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5567
Official Symbol:PRKACB
Other Aliases:DKFZp781I2452|MGC41879|MGC9320|PKACB
See related:HGNC:9381|MIM:176892|HPRD:01482
Chromosome:1
Location:1p36.1
Gene Description:protein kinase, cAMP-dependent, catalytic, beta
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0965
ORGANISM:human
Entrez Gene ID:5567
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:1.2 :: 1.2 :: -2 :: -1.7
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18749CBCerebellum10.908680915832511.7790446281433
18749CTXCerebral cortex100.0100.0
18749HIPHippocampal region35.65175914764454.1607418060303
18749HPFHippocampal formation63.321887969970772.4506874084473
18749HYHypothalamus83.788436889648477.1573104858398
18749LSXLateral septal complex84.570808410644562.8824481964111
18749MBMidbrain69.308158874511756.9959049224854
18749MYMedulla58.287126541137759.9382553100586
18749OLFOlfactory bulb81.62554550170980.0412368774414
18749PPons53.575525283813548.270378112793
18749PALPallidum66.969289779663159.0580997467041
18749RHPRetrohippocampal region91.603496551513792.0268402099609
18749sAMYStriatum-like amygdalar nuclei100.0100.0
18749STRStriatum88.531513214111371.9796600341797
18749STRdStriatum dorsal region86.330772399902366.4630889892578
18749STRvStriatum ventral region88.05279159545963.1920299530029
18749THThalamus31.805235862731925.1125602722168
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5567GO:0000166IEAFunctionnucleotide binding
5567GO:0000287IDAFunctionmagnesium ion binding
5567GO:0004672IEAFunctionprotein kinase activity
5567GO:0004674IEAFunctionprotein serine/threonine kinase activity
5567GO:0004691IDAFunctioncAMP-dependent protein kinase activity
5567GO:0005524IDAFunctionATP binding
5567GO:0005524IEAFunctionATP binding
5567GO:0005634IEAComponentnucleus
5567GO:0005952TASComponentcAMP-dependent protein kinase complex
5567GO:0006468IDAProcessprotein amino acid phosphorylation
5567GO:0006468IEAProcessprotein amino acid phosphorylation
5567GO:0007165TASProcesssignal transduction
5567GO:0007188TASProcessG-protein signaling, coupled to cAMP nucleotide second messenger
5567GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5569NP_006814.1cAMP-dependent protein kinase inhibitor alpha isoform 6HPRD05828
NP_002722.1155030NP_579876.2matrix--
NP_002722.1155030NP_579876.2matrix--
NP_002722.1155030NP_579880.1capsid--
NP_891993.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5567IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
5567IPR000719Prot_kinaseProtein kinase
5567IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
5567IPR001245Tyr_pkinaseTyrosine protein kinase
5567IPR013695WAKWall-associated kinase
5567KAPCB_HUMANP22694IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
5567KAPCB_HUMANP22694IPR000719Prot_kinaseProtein kinase
5567KAPCB_HUMANP22694IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
5567KAPCB_HUMANP22694IPR001245Tyr_pkinaseTyrosine protein kinase
5567KAPCB_HUMANP22694IPR013695WAKWall-associated kinase

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