Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5573
Official Symbol:PRKAR1A
Other Aliases:CAR|CNC1|DKFZp779L0468|MGC17251|PKR1|PRKAR1|TSE1
See related:HGNC:9388|MIM:188830|HPRD:01786
Chromosome:17
Location:17q23-q24
Gene Description:protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0388
ORGANISM:human
Entrez Gene ID:5573
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:1.2 :: -1.6 :: -1.8 :: -1.9 :: -1.8 :: -1.9
KARG Evidence 2
KARG ID:EVIM0456
ORGANISM:human
Entrez Gene ID:5573
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1 :: -1 :: -1.6 :: -4.1 :: -1.6
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
19084CBCerebellum55.8496932983398100.0
19084CTXCerebral cortex100.0100.0
19084HIPHippocampal region100.0100.0
19084HPFHippocampal formation100.0100.0
19084HYHypothalamus100.0100.0
19084LSXLateral septal complex100.0100.0
19084MBMidbrain100.0100.0
19084MYMedulla100.0100.0
19084OLFOlfactory bulb100.0100.0
19084PPons100.0100.0
19084PALPallidum100.0100.0
19084RHPRetrohippocampal region100.0100.0
19084sAMYStriatum-like amygdalar nuclei100.0100.0
19084STRStriatum100.0100.0
19084STRdStriatum dorsal region100.0100.0
19084STRvStriatum ventral region100.0100.0
19084THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5573GO:0000166IEAFunctionnucleotide binding
5573GO:0005515IPIFunctionprotein binding
5573GO:0005952IEAComponentcAMP-dependent protein kinase complex
5573GO:0006357TASProcessregulation of transcription from RNA polymerase II promoter
5573GO:0006468IEAProcessprotein amino acid phosphorylation
5573GO:0007242TASProcessintracellular signaling cascade
5573GO:0008603TASFunctioncAMP-dependent protein kinase regulator activity
5573GO:0030552IEAFunctioncAMP binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-8852NP_003877.2A-kinase anchor protein 4 isoform 1HPRD02173
-11216NP_009133.2A-kinase anchor protein 10 precursorHPRD05259
-9465NP_057461.1A-kinase anchor protein 7 isoform gammaHPRD16065
NP_002725.1--BIG2HPRD01786
NP_002725.1-P03259Early E1A 29.5 kDa protein.BIND151403
NP_002725.111216-A kinase anchor protein 10HPRD01786
NP_002725.18852-A kinase anchor protein 4HPRD01786
NP_002725.15575NP_002726.1protein kinase, cAMP-dependent, regulatory, type I, betaHPRD01786
NP_002725.15575NP_002726.1protein kinase, cAMP-dependent, regulatory, type I, betaHPRD01786
NP_002725.18165NP_003479.1A-kinase anchor protein 1 isoform 1 precursorHPRD03905
NP_002725.18165NP_003479.1A-kinase anchor protein 1 isoform 1 precursorHPRD01786
NP_002725.111215NP_057332.1A-kinase anchor protein 11 isoform 1HPRD01786
NP_002725.111215NP_057332.1A-kinase anchor protein 11 isoform 1HPRD05261
NP_002725.1155871NP_057853.1Tat--
NP_002725.1155030NP_579876.2matrix--
NP_002725.1155030NP_579876.2matrix--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5573KAP0_HUMANP10644IPR002373cAMP_kincAMP-dependent protein kinase
5573KAP0_HUMANP10644IPR000595cNMP_bdCyclic nucleotide-binding
5573KAP0_HUMANP10644IPR003117RIIacAMP-dependent protein kinase regulator, type II PKA R subunit

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