Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5578
Official Symbol:PRKCA
Other Aliases:AAG6|MGC129900|MGC129901|PKC-alpha|PKCA|PRKACA
See related:HGNC:9393|MIM:176960|HPRD:01498
Chromosome:17
Location:17q22-q23.2
Gene Description:protein kinase C, alpha
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0401
ORGANISM:human
Entrez Gene ID:5578
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24680
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18750CBCerebellum4.256737887859345.8158153295517
18750CTXCerebral cortex12.94444221258169.95332014560699
18750HIPHippocampal region47.802518844604561.3395891189575
18750HPFHippocampal formation38.786028861999544.2149348258972
18750HYHypothalamus0.8518853038549420.621179953217506
18750LSXLateral septal complex22.355346202850322.3438489437103
18750MBMidbrain3.99429011344914.47068184614182
18750MYMedulla1.82950198650361.80488449335098
18750OLFOlfactory bulb54.492282867431644.1420192718506
18750PPons1.501219302415851.13195721805096
18750PALPallidum2.086648076772691.99227032065392
18750RHPRetrohippocampal region19.8181706070916.0628648400307
18750sAMYStriatum-like amygdalar nuclei3.265013664960862.41466005146503
18750STRStriatum4.690582752227785.1850580573082
18750STRdStriatum dorsal region3.308684527873994.41001904010773
18750STRvStriatum ventral region4.055594503879553.867700278759
18750THThalamus2.146353960037232.08434545993805
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5578GO:0000074TASProcessregulation of progression through cell cycle
5578GO:0000166IEAFunctionnucleotide binding
5578GO:0004697TASFunctionprotein kinase C activity
5578GO:0005509IEAFunctioncalcium ion binding
5578GO:0005515IPIFunctionprotein binding
5578GO:0005524IEAFunctionATP binding
5578GO:0005624TASComponentmembrane fraction
5578GO:0006468IEAProcessprotein amino acid phosphorylation
5578GO:0007166NRProcesscell surface receptor linked signal transduction
5578GO:0007242IEAProcessintracellular signaling cascade
5578GO:0008270IEAFunctionzinc ion binding
5578GO:0008624TASProcessinduction of apoptosis by extracellular signals
5578GO:0016740IEAFunctiontransferase activity
5578GO:0019992IEAFunctiondiacylglycerol binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7157NP_000537.2tumor protein p53HPRD01859
-5997NP_002914.1regulator of G-protein signalling 2, 24kDaHPRD02917
-7074NP_003244.1T-cell lymphoma invasion and metastasis 1HPRD02820
-7430NP_003370.2villin 2HPRD00475
-7534NP_003397.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptideHPRD03183
-6505NP_004161.3solute carrier family 1, member 1HPRD00597
-9260NP_005442.2PDZ and LIM domain 7 isoform 1HPRD10436
-23650NP_036233.2tripartite motif protein TRIM29 isoform alphaHPRD10280
-5879NP_061485.1ras-related C3 botulinum toxin substrate 1 isoform Rac1bHPRD03627
-60312NP_067651.2actin filament associated proteinHPRD09747
-9464NP_068808.1basic helix-loop-helix transcription factor HAND2HPRD03872
-9138NP_945353.1Rho guanine nucleotide exchange factor 1 isoform 1HPRD03511
-8525Q13574Diacylglycerol kinase zeta (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).HPRD03260
NP_002728.16402NP_000646.1selectin LBIND169390
NP_002728.16406NP_002998.1semenogelin I isoform a preproproteinHPRD01641
NP_002728.16624NP_003079.1fascin 1HPRD04068
NP_002728.17015NP_003210.1telomerase reverse transcriptase isoform 1HPRD01754
NP_002728.18436NP_004648.1serum deprivation response proteinHPRD09470
NP_002728.19590NP_005091.2A-kinase anchor protein 12 isoform 1HPRD05263
NP_002728.111214NP_006729.4A-kinase anchor protein 13 isoform 1BIND178785
NP_002728.111033NP_006860.1centaurin, alpha 1HPRD09733
NP_002728.17011NP_009041.2telomerase-associated protein 1HPRD03404
NP_002728.16814NP_009200.1syntaxin binding protein 3HPRD10517
NP_002728.17532NP_036611.2tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideHPRD05639
NP_002728.122927NP_055097.1hyaluronan binding protein 4HPRD13628
NP_002728.194274NP_150281.1protein phosphatase 1, regulatory (inhibitor) subunit 14AHPRD16291
NP_002728.123704NP_542402.1potassium voltage-gated channel, Isk-related family, member 4HPRD09689
NP_002728.1155871NP_057853.1Tat--
NP_002728.1155871NP_057853.1Tat--
NP_002728.1155871NP_057853.1Tat--
NP_002728.1155908NP_057854.1Rev--
NP_002728.1155030NP_579876.2matrix--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5578KPCA_HUMANP17252IPR000008C2C2
5578KPCA_HUMANP17252IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
5578KPCA_HUMANP17252IPR002219DAG_PE_bdProtein kinase C, phorbol ester/diacylglycerol binding
5578KPCA_HUMANP17252IPR000961Pkinase_CProtein kinase, C-terminal
5578KPCA_HUMANP17252IPR000719Prot_kinaseProtein kinase
5578KPCA_HUMANP17252IPR013583PRT_C_plnPhosphoribosyltransferase C-terminal, plant
5578KPCA_HUMANP17252IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
5578KPCA_HUMANP17252IPR001245Tyr_pkinaseTyrosine protein kinase
5578KPCA_HUMANP17252IPR013695WAKWall-associated kinase

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