Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5581
Official Symbol:PRKCE
Other Aliases:MGC125656|MGC125657|PKCE|nPKC-epsilon
See related:HGNC:9401|MIM:176975|HPRD:01500
Chromosome:2
Location:2p21
Gene Description:protein kinase C, epsilon
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0027
ORGANISM:human
Entrez Gene ID:5581
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:18754
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0403
ORGANISM:human
Entrez Gene ID:5581
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:29340
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18754CBCerebellum84.3469924926758100.0
18754CTXCerebral cortex100.0100.0
18754HIPHippocampal region100.0100.0
18754HPFHippocampal formation100.0100.0
18754HYHypothalamus81.831695556640682.6807632446289
18754LSXLateral septal complex100.0100.0
18754MBMidbrain79.733238220214887.4228286743164
18754MYMedulla72.887001037597792.4458999633789
18754OLFOlfactory bulb100.0100.0
18754PPons64.290237426757885.3276672363281
18754PALPallidum97.4962310791016100.0
18754RHPRetrohippocampal region100.0100.0
18754sAMYStriatum-like amygdalar nuclei100.0100.0
18754STRStriatum100.0100.0
18754STRdStriatum dorsal region100.0100.0
18754STRvStriatum ventral region100.0100.0
18754THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5581GO:0000166IEAFunctionnucleotide binding
5581GO:0004697TASFunctionprotein kinase C activity
5581GO:0004871TASFunctionsignal transducer activity
5581GO:0005524IEAFunctionATP binding
5581GO:0005624TASComponentmembrane fraction
5581GO:0006468TASProcessprotein amino acid phosphorylation
5581GO:0006917TASProcessinduction of apoptosis
5581GO:0007242IEAProcessintracellular signaling cascade
5581GO:0008270IEAFunctionzinc ion binding
5581GO:0016740IEAFunctiontransferase activity
5581GO:0019992IEAFunctiondiacylglycerol binding
5581GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6622NP_000336.1alpha-synuclein isoform NACP140HPRD01227
-5894NP_002871.1v-raf-1 murine leukemia viral oncogene homolog 1HPRD01265
-7074NP_003244.1T-cell lymphoma invasion and metastasis 1HPRD02820
-7416NP_003365.1voltage-dependent anion channel 1HPRD05137
-9276NP_004757.1coatomer protein complex, subunit beta 2 (beta prime)HPRD06103
-6714NP_005408.1proto-oncogene tyrosine-protein kinase SRCHPRD01819
-10611NP_006448.1PDZ and LIM domain 5HPRD05799
-60312NP_067651.2actin filament associated proteinHPRD09747
-10142NP_671700.1A-kinase anchor protein 9 isoform 1HPRD04921
NP_005391.15587NP_002733.1protein kinase D1BIND262383
NP_005391.15581NP_005391.1protein kinase C, epsilonBIND262386
NP_005391.110672NP_006563.2guanine nucleotide binding protein (G protein), alpha 13HPRD05100
NP_005391.194274NP_150281.1protein phosphatase 1, regulatory (inhibitor) subunit 14AHPRD16291
NP_005391.1155871NP_057853.1Tat--
NP_005391.1155871NP_057853.1Tat--
NP_005391.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5581KPCE_HUMANQ02156IPR000008C2C2
5581KPCE_HUMANQ02156IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
5581KPCE_HUMANQ02156IPR002219DAG_PE_bdProtein kinase C, phorbol ester/diacylglycerol binding
5581KPCE_HUMANQ02156IPR000961Pkinase_CProtein kinase, C-terminal
5581KPCE_HUMANQ02156IPR000719Prot_kinaseProtein kinase
5581KPCE_HUMANQ02156IPR013583PRT_C_plnPhosphoribosyltransferase C-terminal, plant
5581KPCE_HUMANQ02156IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
5581KPCE_HUMANQ02156IPR001245Tyr_pkinaseTyrosine protein kinase
5581KPCE_HUMANQ02156IPR013695WAKWall-associated kinase

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