Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5590
Official Symbol:PRKCZ
Other Aliases:PKC2
See related:HGNC:9412|MIM:176982|HPRD:01504
Chromosome:1
Location:1p36.33-p36.2
Gene Description:protein kinase C, zeta
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0962
ORGANISM:human
Entrez Gene ID:5590
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.1 :: 1 :: 1.4 :: 1.8
KARG Evidence 2
KARG ID:QTL0086
ORGANISM:human
Entrez Gene ID:5590
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:QTL0087
ORGANISM:human
Entrez Gene ID:5590
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 4
KARG ID:QTL0088
ORGANISM:human
Entrez Gene ID:5590
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18762CBCerebellum43.927635192871132.3509049415588
18762CTXCerebral cortex58.416722297668555.2532143592834
18762HIPHippocampal region53.139731407165548.2612142562866
18762HPFHippocampal formation63.355286598205656.3097620010376
18762HYHypothalamus28.602701902389520.5846663117409
18762LSXLateral septal complex38.138397514820123.5819647014141
18762MBMidbrain33.31264698505427.2262158989906
18762MYMedulla39.677922487258936.1584646701813
18762OLFOlfactory bulb64.888112068176354.0743198394775
18762PPons53.268742322921847.9402108192444
18762PALPallidum23.698524713516219.2729331851006
18762RHPRetrohippocampal region61.795179367065458.0504970550537
18762sAMYStriatum-like amygdalar nuclei50.761544227600131.5405488014221
18762STRStriatum50.397245883941732.4572558403015
18762STRdStriatum dorsal region51.986322879791334.8026194572449
18762STRvStriatum ventral region51.798577308654829.755117893219
18762THThalamus50.064072132110641.6183576583862
KARG Evidence 5
KARG ID:QTL0086
Trait:cocaine related behavior
Peak:83
Peak Marker: 34M15-SP6
Parents:BXD/Ty (B = C57BL/6, D = DBA/2) recombinant inbred
Evidence ID:10591541
KARG Evidence 6
KARG ID:QTL0087
Trait:ethanol conditioned taste aversion
Peak:83
Peak Marker:D4Ncvs25
Parents:20 BXD/Ty RI strains
Evidence ID:9756038
KARG Evidence 7
KARG ID:QTL0088
Trait:METH responses for climbing
Peak:83
Peak Marker:Sac
Parents:C57BL/6J x DBA/2J intercross
Evidence ID:8987796
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5590GO:0000166IEAFunctionnucleotide binding
5590GO:0004674IEAFunctionprotein serine/threonine kinase activity
5590GO:0004700TASFunctionatypical protein kinase C activity
5590GO:0005515IPIFunctionprotein binding
5590GO:0005524IEAFunctionATP binding
5590GO:0005624TASComponentmembrane fraction
5590GO:0005737TASComponentcytoplasm
5590GO:0005886TASComponentplasma membrane
5590GO:0006468IEAProcessprotein amino acid phosphorylation
5590GO:0006468TASProcessprotein amino acid phosphorylation
5590GO:0006916TASProcessanti-apoptosis
5590GO:0007242IEAProcessintracellular signaling cascade
5590GO:0008270IEAFunctionzinc ion binding
5590GO:0016740IEAFunctiontransferase activity
5590GO:0019992IEAFunctiondiacylglycerol binding
5590GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5894NP_002871.1v-raf-1 murine leukemia viral oncogene homolog 1HPRD01265
-7529NP_003395.1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideHPRD03184
-8471NP_003595.1insulin receptor substrate 4HPRD04620
-8772NP_003815.1Fas-associated via death domainHPRD03909
-9637NP_005093.1zygin 2HPRD09213
-9638NP_005094.1zygin 1 isoform 1HPRD09212
-6714NP_005408.1proto-oncogene tyrosine-protein kinase SRCHPRD01819
-9260NP_005442.2PDZ and LIM domain 7 isoform 1HPRD10436
-10000NP_005456.1v-akt murine thymoma viral oncogene homolog 3 isoform 1HPRD06441
-60312NP_067651.2actin filament associated proteinHPRD09747
-5970NP_068810.1v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65HPRD01241
-84552NP_115899.1PAR-6 gamma proteinHPRD10138
-5607NP_660144.1mitogen-activated protein kinase kinase 5 isoform CHPRD03951
-7189NP_665802.1TNF receptor-associated factor 6HPRD03833
NP_002735.28878NP_003891.1sequestosome 1HPRD03319
NP_002735.211033NP_006860.1centaurin, alpha 1HPRD09733
NP_002735.222927NP_055097.1hyaluronan binding protein 4HPRD13628
NP_002735.223286NP_056053.1KIBRA proteinHPRD10033
NP_002735.250855NP_058644.1partitioning defective-6 homolog alpha isoform 1HPRD06316
NP_002735.294274NP_150281.1protein phosphatase 1, regulatory (inhibitor) subunit 14AHPRD16291
NP_002735.2155871NP_057853.1Tat--
NP_002735.2155871NP_057853.1Tat--
NP_002735.2155871NP_057853.1Tat--
NP_002735.3---BIND217802
NP_002735.35590NP_002735.3protein kinase C, zeta isoform 1BIND209434
NP_002735.38878NP_003891.1sequestosome 1BIND295420
NP_002735.36774NP_644805.1signal transducer and activator of transcription 3 isoform 1BIND300769
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5590KPCZ_HUMANQ05513IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
5590KPCZ_HUMANQ05513IPR002219DAG_PE_bdProtein kinase C, phorbol ester/diacylglycerol binding
5590KPCZ_HUMANQ05513IPR000270OPR_PB1Octicosapeptide/Phox/Bem1p
5590KPCZ_HUMANQ05513IPR000961Pkinase_CProtein kinase, C-terminal
5590KPCZ_HUMANQ05513IPR000719Prot_kinaseProtein kinase
5590KPCZ_HUMANQ05513IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
5590KPCZ_HUMANQ05513IPR001245Tyr_pkinaseTyrosine protein kinase
5590KPCZ_HUMANQ05513IPR013695WAKWall-associated kinase

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