Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5594
Official Symbol:MAPK1
Other Aliases:ERK|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk
See related:HGNC:6871|MIM:176948|HPRD:01496
Chromosome:22
Location:22q11.2|22q11.21
Gene Description:mitogen-activated protein kinase 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0271
ORGANISM:human
Entrez Gene ID:5594
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:26413
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0493
ORGANISM:human
Entrez Gene ID:5594
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:116590
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVIL0247
ORGANISM:human
Entrez Gene ID:5594
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15198681
Addiction Drug:OPIOINS
Addiction Drug Detail:Chronic opiate addiction,Downregulations of phosphorylated ERK1 (81%)
Addiction Brain Area:PFC
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
26413CBCerebellum63.4239692687988100.0
26413CTXCerebral cortex100.0100.0
26413HIPHippocampal region100.0100.0
26413HPFHippocampal formation100.0100.0
26413HYHypothalamus100.0100.0
26413LSXLateral septal complex100.0100.0
26413MBMidbrain100.0100.0
26413MYMedulla100.0100.0
26413OLFOlfactory bulb100.0100.0
26413PPons97.9509506225586100.0
26413PALPallidum100.0100.0
26413RHPRetrohippocampal region100.0100.0
26413sAMYStriatum-like amygdalar nuclei100.0100.0
26413STRStriatum100.0100.0
26413STRdStriatum dorsal region100.0100.0
26413STRvStriatum ventral region100.0100.0
26413THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5594GO:0000166IEAFunctionnucleotide binding
5594GO:0004674IEAFunctionprotein serine/threonine kinase activity
5594GO:0004707TASFunctionMAP kinase activity
5594GO:0005524IEAFunctionATP binding
5594GO:0006468IEAProcessprotein amino acid phosphorylation
5594GO:0006917TASProcessinduction of apoptosis
5594GO:0006935TASProcesschemotaxis
5594GO:0006950TASProcessresponse to stress
5594GO:0007049IEAProcesscell cycle
5594GO:0007165TASProcesssignal transduction
5594GO:0007268TASProcesssynaptic transmission
5594GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7175AAB48030.1Human nuclear pore complex-associated protein TPR (tpr) mRNA, and translated productsHPRD08927
-5925NP_000312.1retinoblastoma 1BIND182236
-6622NP_000336.1alpha-synuclein isoform NACP140HPRD01227
-5794NP_002833.1protein tyrosine phosphatase, receptor type, H precursorHPRD03942
-5801NP_002840.1protein tyrosine phosphatase, receptor type, R isoform 1 precursorHPRD04169
-8462NP_003588.1Kruppel-like factor 11HPRD04488
-8600NP_003692.1tumor necrosis factor ligand superfamily, member 11 isoform 1HPRD04031
-6197NP_004577.1ribosomal protein S6 kinase, 90kDa, polypeptide 3HPRD02092
-6721NP_004590.2sterol regulatory element-binding transcription factor 2HPRD02726
-9149NP_004705.1dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B isoform aHPRD05188
-7409NP_005419.2vav 1 oncogeneHPRD01284
-10140NP_005740.1transducer of ERBB2, 1HPRD09273
-9759NP_006028.1histone deacetylase 4HPRD05610
-51366NP_056986.2E3 ubiquitin protein ligase, HECT domain containing, 1HPRD06436
-57658NP_065949.1coiled-coil transcriptional coactivatorBIND182235
-6196NP_066958.2ribosomal protein S6 kinase, 90kDa, polypeptide 2 isoform aHPRD03403
-8649NP_068805.1mitogen-activated protein kinase kinase 1 interacting protein 1HPRD04485
-5605NP_109587.1mitogen-activated protein kinase kinase 2HPRD03164
-283455NP_775869.2kinase suppressor of ras 2HPRD13952
-6464NP_892113.1SHC (Src homology 2 domain containing) transforming protein 1HPRD02780
NP_002736.2-P03401Virion infectivity factor (SOR protein).BIND257737
NP_002736.27249--BIND262796
NP_002736.25894NP_002871.1v-raf-1 murine leukemia viral oncogene homolog 1BIND208307
NP_002736.26195NP_002944.2ribosomal protein S6 kinase, 90kDa, polypeptide 1 isoform aHPRD03402
NP_002736.26776NP_003143.2signal transducer and activator of transcription 5AHPRD03301
NP_002736.28682NP_003759.1phosphoprotein enriched in astrocytes 15HPRD04579
NP_002736.28986NP_003933.1ribosomal protein S6 kinase, 90kDa, polypeptide 4 isoform aHPRD04677
NP_002736.27409NP_005419.2vav 1 oncogeneBIND12812
NP_002736.210318NP_006049.2Nef-associated factor 1BIND12882
NP_002736.26777NP_036580.2signal transducer and activator of transcription 5BHPRD05037
NP_002736.26196NP_066958.2ribosomal protein S6 kinase, 90kDa, polypeptide 2 isoform aBIND123291
NP_002736.280824NP_085143.1dual specificity phosphatase 16HPRD09525
NP_002736.25778NP_542155.1protein tyrosine phosphatase, non-receptor type 7 isoform 2HPRD01480
NP_002736.28550NP_620777.1mitogen-activated protein kinase-activated protein kinase 5 isoform 2HPRD09467
NP_002736.2155459NP_057851.1Vif--
NP_002736.2155871NP_057853.1Tat--
NP_002736.2155871NP_057853.1Tat--
NP_002736.2155871NP_057853.1Tat--
NP_002736.2155908NP_057854.1Rev--
NP_002736.2155030NP_579876.2matrix--
NP_002736.2155030NP_579876.2matrix--
NP_002736.2155030NP_579883.1p6--
NP_620407.15604NP_002746.1mitogen-activated protein kinase kinase 1BIND12804
NP_620407.15605NP_109587.1mitogen-activated protein kinase kinase 2BIND12805
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5594MK01_HUMANP28482IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
5594MK01_HUMANP28482IPR008349Erk_1_2_MAPKERK1/2 MAP kinase
5594MK01_HUMANP28482IPR008350Erk_3_4_MAPKERK3/4 MAP kinase
5594MK01_HUMANP28482IPR008351JNK_MAPKJNK MAP kinase
5594MK01_HUMANP28482IPR003527MAP_kinMAP kinase
5594MK01_HUMANP28482IPR008352p38_MAPKp38 MAP kinase
5594MK01_HUMANP28482IPR000719Prot_kinaseProtein kinase
5594MK01_HUMANP28482IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
5594MK01_HUMANP28482IPR001245Tyr_pkinaseTyrosine protein kinase
5594MK01_HUMANP28482IPR013695WAKWall-associated kinase

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