Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5595
Official Symbol:MAPK3
Other Aliases:ERK1|HS44KDAP|HUMKER1A|MGC20180|P44ERK1|P44MAPK|PRKM3
See related:HGNC:6877|MIM:601795|HPRD:03479
Chromosome:16
Location:16p11.2
Gene Description:mitogen-activated protein kinase 3
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0078
ORGANISM:human
Entrez Gene ID:5595
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:26417
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0492
ORGANISM:human
Entrez Gene ID:5595
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:50689
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVIM0151
ORGANISM:human
Entrez Gene ID:5595
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:1.12 :: 0.09 :: 0.07 :: 0.78 :: -0.32 :: -0.96 :: 1.90
KARG Evidence 4
KARG ID:EVIL0248
ORGANISM:human
Entrez Gene ID:5595
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15198681
Addiction Drug:OPIOINS
Addiction Drug Detail:Chronic opiate addiction, Downregulations of phosphorylated ERK2 (80%)
Addiction Brain Area:PFC
Drug Effects:
Fold Change:
KARG Evidence 5
KARG ID:EVID0021
ORGANISM:human
Entrez Gene ID:5595
Evidence Type:Database Annotations
Evidence ID Type:OMIM
Evidence ID:MIM:601795
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
26417CBCerebellum41.850164413452174.521110534668
26417CTXCerebral cortex73.604278564453169.4136161804199
26417HIPHippocampal region87.0143585205078100.0
26417HPFHippocampal formation86.814071655273496.802173614502
26417HYHypothalamus68.723325729370166.7358283996582
26417LSXLateral septal complex63.597031593322861.2820701599121
26417MBMidbrain67.696748733520567.3506641387939
26417MYMedulla72.282266616821377.99342918396
26417OLFOlfactory bulb89.539901733398493.184154510498
26417PPons68.893453598022571.3400344848633
26417PALPallidum66.997550964355567.2748336791992
26417RHPRetrohippocampal region83.584861755371183.8313636779785
26417sAMYStriatum-like amygdalar nuclei71.16907501220767.2695446014404
26417STRStriatum68.924303054809665.3226337432861
26417STRdStriatum dorsal region66.23815155029363.568398475647
26417STRvStriatum ventral region78.901777267456171.0351142883301
26417THThalamus71.136430740356468.1255474090576
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5595GO:0000074NASProcessregulation of progression through cell cycle
5595GO:0000166IEAFunctionnucleotide binding
5595GO:0004674IEAFunctionprotein serine/threonine kinase activity
5595GO:0004707IEAFunctionMAP kinase activity
5595GO:0004707NASFunctionMAP kinase activity
5595GO:0005515IPIFunctionprotein binding
5595GO:0005524IEAFunctionATP binding
5595GO:0005524NASFunctionATP binding
5595GO:0006468IDAProcessprotein amino acid phosphorylation
5595GO:0006468IEAProcessprotein amino acid phosphorylation
5595GO:0007049IEAProcesscell cycle
5595GO:0008372NDComponentcellular component unknown
5595GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7157NP_000537.2tumor protein p53HPRD01859
-5801NP_002840.1protein tyrosine phosphatase, receptor type, R isoform 1 precursorHPRD04169
-8600NP_003692.1tumor necrosis factor ligand superfamily, member 11 isoform 1HPRD04031
-6197NP_004577.1ribosomal protein S6 kinase, 90kDa, polypeptide 3HPRD02092
-6721NP_004590.2sterol regulatory element-binding transcription factor 2HPRD02726
-9759NP_006028.1histone deacetylase 4HPRD05610
-6196NP_066958.2ribosomal protein S6 kinase, 90kDa, polypeptide 2 isoform aHPRD03403
-8649NP_068805.1mitogen-activated protein kinase kinase 1 interacting protein 1HPRD04485
-5605NP_109587.1mitogen-activated protein kinase kinase 2HPRD03164
-5778NP_542155.1protein tyrosine phosphatase, non-receptor type 7 isoform 2HPRD01480
-283455NP_775869.2kinase suppressor of ras 2HPRD13952
-7054NP_954986.1tyrosine hydroxylase isoform aHPRD01865
-6689Q01892Transcription factor Spi-B.HPRD06007
AAH13992.15604NP_002746.1mitogen-activated protein kinase kinase 1BIND12802
AAH13992.15605NP_109587.1mitogen-activated protein kinase kinase 2BIND12803
NP_002737.1--PTP-SLHPRD03479
NP_002737.1--Primase polypeptide 2BHPRD03479
NP_002737.1--Vinexin betaHPRD03479
NP_002737.17054-Tyrosine hydroxylaseHPRD03479
NP_002737.15604-MEK1HPRD03479
NP_002737.15605-MAP2K2HPRD03479
NP_002737.16689-SPIB transcription factorHPRD03479
NP_002737.16196-Ribosomal S6 kinase 3HPRD03479
NP_002737.16196--BIND196717
NP_002737.18649-MEK partner 1HPRD03479
NP_002737.15801-Phosphotyrosine phosphatase, receptor, type RHPRD03479
NP_002737.184867-Protein tyrosine phosphatase, non receptor type 5HPRD03479
NP_002737.15778-Protein tyrosine phosphatase nonreceptor 7HPRD03479
NP_002737.16721-SREBP2HPRD03479
NP_002737.18600-Tumor necrosis factor ligand superfamily, member 11HPRD03479
NP_002737.17157-p53HPRD03479
NP_002737.19759-Histone deacetylase 4HPRD03479
NP_002737.16197-Ribosomal protein S6 kinase alpha 3HPRD03479
NP_002737.18569BAA19885.1MNK1BIND196643
NP_002737.17155NP_001059.2DNA topoisomerase II, beta isozymeBIND196721
NP_002737.16195NP_002944.2ribosomal protein S6 kinase, 90kDa, polypeptide 1 isoform aHPRD03479
NP_002737.16195NP_002944.2ribosomal protein S6 kinase, 90kDa, polypeptide 1 isoform aHPRD03402
NP_002737.17553NP_003407.1zinc finger protein 7 (KOX 4, clone HF.16)BIND196718
NP_002737.18682NP_003759.1phosphoprotein enriched in astrocytes 15HPRD03479
NP_002737.18682NP_003759.1phosphoprotein enriched in astrocytes 15HPRD04579
NP_002737.18682NP_003759.1phosphoprotein enriched in astrocytes 15BIND197139
NP_002737.18986NP_003933.1ribosomal protein S6 kinase, 90kDa, polypeptide 4 isoform aHPRD04677
NP_002737.18986NP_003933.1ribosomal protein S6 kinase, 90kDa, polypeptide 4 isoform aHPRD03479
NP_002737.16887NP_005412.1T-cell acute lymphocytic leukemia 2HPRD03479
NP_002737.16887NP_005412.1T-cell acute lymphocytic leukemia 2HPRD01735
NP_002737.110174NP_005766.2vinexin beta (SH3-containing adaptor molecule-1) isoform 1HPRD11535
NP_002737.15900NP_006257.1ral guanine nucleotide dissociation stimulatorBIND196722
NP_002737.111221NP_009138.1dual specificity phosphatase 10 isoform aHPRD12320
NP_002737.1153572NP_150366.1iroquois homeobox protein 2BIND217481
NP_002737.15606NP_659732.1mitogen-activated protein kinase kinase 3 isoform CHPRD03479
NP_002737.15606NP_659732.1mitogen-activated protein kinase kinase 3 isoform CHPRD03816
NP_002737.1155459NP_057851.1Vif--
NP_002737.1155871NP_057853.1Tat--
NP_002737.1155871NP_057853.1Tat--
NP_002737.1155871NP_057853.1Tat--
NP_002737.1155908NP_057854.1Rev--
NP_002737.1155030NP_579876.2matrix--
NP_002737.1155030NP_579876.2matrix--
NP_002737.1155030NP_579883.1p6--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5595MK03_HUMANP27361IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
5595MK03_HUMANP27361IPR008349Erk_1_2_MAPKERK1/2 MAP kinase
5595MK03_HUMANP27361IPR008350Erk_3_4_MAPKERK3/4 MAP kinase
5595MK03_HUMANP27361IPR008351JNK_MAPKJNK MAP kinase
5595MK03_HUMANP27361IPR003527MAP_kinMAP kinase
5595MK03_HUMANP27361IPR008352p38_MAPKp38 MAP kinase
5595MK03_HUMANP27361IPR000719Prot_kinaseProtein kinase
5595MK03_HUMANP27361IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
5595MK03_HUMANP27361IPR001245Tyr_pkinaseTyrosine protein kinase
5595MK03_HUMANP27361IPR013695WAKWall-associated kinase

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