Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5599
Official Symbol:MAPK8
Other Aliases:JNK|JNK1|JNK1A2|JNK21B1/2|PRKM8|SAPK1
See related:HGNC:6881|MIM:601158|HPRD:03100
Chromosome:10
Location:10q11.22
Gene Description:mitogen-activated protein kinase 8
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0240
ORGANISM:human
Entrez Gene ID:5599
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Upregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
26419CBCerebellum17.374214172363319.4594039916992
26419CTXCerebral cortex58.156324386596748.8146591186523
26419HIPHippocampal region36.744859695434645.880407333374
26419HPFHippocampal formation47.846485137939553.310022354126
26419HYHypothalamus7.225524425506595.62185263633728
26419LSXLateral septal complex9.106953263282788.52234673500061
26419MBMidbrain11.931167125701911.3502511978149
26419MYMedulla17.890147209167521.5583662986755
26419OLFOlfactory bulb49.597894668579146.0268650054932
26419PPons16.03367948532117.3051819801331
26419PALPallidum16.429383277893116.0838265419006
26419RHPRetrohippocampal region66.55373191833563.7538623809814
26419sAMYStriatum-like amygdalar nuclei21.224814891815216.6825160980225
26419STRStriatum14.653737306594811.8272507190704
26419STRdStriatum dorsal region14.290402650833111.6892430782318
26419STRvStriatum ventral region14.02771139144910.3648855686188
26419THThalamus27.653893470764223.4405241012573
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5599GO:0000166IEAFunctionnucleotide binding
5599GO:0004674IEAFunctionprotein serine/threonine kinase activity
5599GO:0004705IDAFunctionJUN kinase activity
5599GO:0004707IEAFunctionMAP kinase activity
5599GO:0005515IPIFunctionprotein binding
5599GO:0005524IEAFunctionATP binding
5599GO:0006468IEAProcessprotein amino acid phosphorylation
5599GO:0006928TASProcesscell motility
5599GO:0006950TASProcessresponse to stress
5599GO:0007165TASProcesssignal transduction
5599GO:0007254IDAProcessJNK cascade
5599GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5609AAC16273.1Homo sapiens mitogen-activated protein kinase kinase 7b (MKK7b) mRNA, complete cds.HPRD04309
-7157NP_000537.2tumor protein p53HPRD01859
-6416NP_003001.1mitogen-activated protein kinase kinase 4HPRD03213
-6416NP_003001.1mitogen-activated protein kinase kinase 4BIND193720
-8518NP_003631.1inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated proteinHPRD04763
-9466NP_004834.1class I cytokine receptorHPRD09247
-9467NP_004835.1SH3-domain binding protein 5 (BTK-associated) isoform aHPRD12030
-9479NP_005447.1mitogen-activated protein kinase 8 interacting protein 1HPRD05223
-10746NP_006600.2mitogen-activated protein kinase kinase kinase 2HPRD10068
-11221NP_009138.1dual specificity phosphatase 10 isoform aBIND257581
-23162NP_055948.1mitogen-activated protein kinase 8 interacting protein 3 isoform 1HPRD12014
-5609NP_660186.1mitogen-activated protein kinase kinase 7BIND193719
-6689Q01892Transcription factor Spi-B.HPRD06007
NP_002741.19467NP_004835.1SH3-domain binding protein 5 (BTK-associated) isoform aBIND12921
NP_620634.19467NP_004835.1SH3-domain binding protein 5 (BTK-associated) isoform aBIND12926
NP_620635.19467NP_004835.1SH3-domain binding protein 5 (BTK-associated) isoform aBIND12928
NP_620637.1--JNKBP1HPRD03100
NP_620637.1--JIP-2HPRD03100
NP_620637.1--JIP-3HPRD03100
NP_620637.16689-SPIB transcription factorHPRD03100
NP_620637.15609-MAP2K7HPRD03100
NP_620637.17157-p53HPRD03100
NP_620637.16416-MAP2K4HPRD03100
NP_620637.19479-MAPK8 interacting protein 1HPRD03100
NP_620637.18518-IKAPHPRD03100
NP_620637.19466-Interleukin 27 receptorHPRD03100
NP_620637.15966NP_002899.1v-rel reticuloendotheliosis viral oncogene homologHPRD03100
NP_620637.15966NP_002899.1v-rel reticuloendotheliosis viral oncogene homologHPRD01286
NP_620637.16623NP_003078.1synuclein, gamma (breast cancer-specific protein 1)HPRD03100
NP_620637.16623NP_003078.1synuclein, gamma (breast cancer-specific protein 1)HPRD04297
NP_620637.18600NP_003692.1tumor necrosis factor ligand superfamily, member 11 isoform 1HPRD03100
NP_620637.18600NP_003692.1tumor necrosis factor ligand superfamily, member 11 isoform 1HPRD04031
NP_620637.19043NP_003962.3sperm associated antigen 9 isoform 1HPRD10398
NP_620637.19318NP_004227.1COP9 constitutive photomorphogenic homolog subunit 2HPRD03100
NP_620637.19318NP_004227.1COP9 constitutive photomorphogenic homolog subunit 2HPRD05146
NP_620637.19467NP_004835.1SH3-domain binding protein 5 (BTK-associated) isoform aBIND12925
NP_620637.111221NP_009138.1dual specificity phosphatase 10 isoform aHPRD12320
NP_620637.123542NP_036456.1mitogen-activated protein kinase 8 interacting protein 2 isoform 1HPRD09674
NP_620637.123542NP_036456.1mitogen-activated protein kinase 8 interacting protein 2 isoform 1HPRD03100
NP_620637.151741NP_057457.1WW domain-containing oxidoreductase isoform 1HPRD05501
NP_620637.156940NP_064570.1dual specificity phosphatase 22HPRD13255
NP_620637.180824NP_085143.1dual specificity phosphatase 16HPRD09525
NP_620637.180824NP_085143.1dual specificity phosphatase 16HPRD03100
NP_620637.16885NP_663304.1mitogen-activated protein kinase kinase kinase 7 isoform BHPRD04011
NP_620637.16885NP_663304.1mitogen-activated protein kinase kinase kinase 7 isoform BHPRD03100
NP_620637.1155871NP_057853.1Tat--
NP_620637.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5599IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
5599IPR008351JNK_MAPKJNK MAP kinase
5599IPR003527MAP_kinMAP kinase
5599IPR000719Prot_kinaseProtein kinase
5599IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
5599IPR001245Tyr_pkinaseTyrosine protein kinase
5599IPR013695WAKWall-associated kinase
5599MK08_HUMANP45983IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
5599MK08_HUMANP45983IPR008351JNK_MAPKJNK MAP kinase
5599MK08_HUMANP45983IPR003527MAP_kinMAP kinase
5599MK08_HUMANP45983IPR000719Prot_kinaseProtein kinase
5599MK08_HUMANP45983IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
5599MK08_HUMANP45983IPR013695WAKWall-associated kinase

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