Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5601
Official Symbol:MAPK9
Other Aliases:JNK-55|JNK2|JNK2A|JNK2ALPHA|JNK2B|JNK2BETA|PRKM9|p54aSAPK
See related:HGNC:6886|MIM:602896|HPRD:04206
Chromosome:5
Location:5q35
Gene Description:mitogen-activated protein kinase 9
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0507
ORGANISM:human
Entrez Gene ID:5601
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:50658
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
26420CBCerebellum22.89261436462438.2372360229492
26420CTXCerebral cortex86.152206420898481.4353256225586
26420HIPHippocampal region47.486366271972764.1367950439453
26420HPFHippocampal formation54.454627990722763.8786506652832
26420HYHypothalamus74.838119506835971.9858856201172
26420LSXLateral septal complex32.04229354858427.9806995391846
26420MBMidbrain52.224239349365260.2057456970215
26420MYMedulla43.901325225830172.1265640258789
26420OLFOlfactory bulb61.673221588134863.7737655639648
26420PPons50.730484008789178.8815841674805
26420PALPallidum58.463542938232467.4884719848633
26420RHPRetrohippocampal region76.011352539062570.9055480957031
26420sAMYStriatum-like amygdalar nuclei79.823997497558673.5770263671875
26420STRStriatum38.050659179687533.5810737609863
26420STRdStriatum dorsal region26.93520927429223.5424842834473
26420STRvStriatum ventral region55.471664428710946.1158180236816
26420THThalamus61.898033142089862.8023338317871
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5601GO:0000166IEAFunctionnucleotide binding
5601GO:0004674IEAFunctionprotein serine/threonine kinase activity
5601GO:0004705IDAFunctionJUN kinase activity
5601GO:0004707IEAFunctionMAP kinase activity
5601GO:0005515IPIFunctionprotein binding
5601GO:0005524IEAFunctionATP binding
5601GO:0006468IEAProcessprotein amino acid phosphorylation
5601GO:0006950TASProcessresponse to stress
5601GO:0007254IDAProcessJNK cascade
5601GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7157NP_000537.2tumor protein p53HPRD01859
-23162NP_055948.1mitogen-activated protein kinase 8 interacting protein 3 isoform 1HPRD12014
-7186NP_066961.2TNF receptor-associated factor 2HPRD03538
NP_002743.3--JNKBP1HPRD04206
NP_002743.3--JSAP1aHPRD04206
NP_002743.37157-p53HPRD04206
NP_002743.37186-TRAF2HPRD04206
NP_002743.35925NP_000312.1retinoblastoma 1BIND55021
NP_002743.39467NP_004835.1SH3-domain binding protein 5 (BTK-associated) isoform aHPRD12030
NP_002743.39467NP_004835.1SH3-domain binding protein 5 (BTK-associated) isoform aBIND12930
NP_002743.311016NP_006847.1activating transcription factor 7HPRD04206
NP_002743.311016NP_006847.1activating transcription factor 7HPRD06968
NP_002743.380824NP_085143.1dual specificity phosphatase 16HPRD09525
NP_002743.380824NP_085143.1dual specificity phosphatase 16HPRD04206
NP_002743.3142679NP_543152.1dual specificity phosphatase 19HPRD13254
NP_002743.38550NP_620777.1mitogen-activated protein kinase-activated protein kinase 5 isoform 2HPRD09467
NP_002743.38550NP_620777.1mitogen-activated protein kinase-activated protein kinase 5 isoform 2HPRD04206
NP_620707.19467NP_004835.1SH3-domain binding protein 5 (BTK-associated) isoform aBIND12929
NP_620708.19467NP_004835.1SH3-domain binding protein 5 (BTK-associated) isoform aBIND12931
NP_620709.19467NP_004835.1SH3-domain binding protein 5 (BTK-associated) isoform aBIND12932
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5601IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
5601IPR008351JNK_MAPKJNK MAP kinase
5601IPR003527MAP_kinMAP kinase
5601IPR000719Prot_kinaseProtein kinase
5601IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
5601IPR001245Tyr_pkinaseTyrosine protein kinase
5601IPR013695WAKWall-associated kinase
5601MK09_HUMANP45984IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
5601MK09_HUMANP45984IPR008351JNK_MAPKJNK MAP kinase
5601MK09_HUMANP45984IPR003527MAP_kinMAP kinase
5601MK09_HUMANP45984IPR000719Prot_kinaseProtein kinase
5601MK09_HUMANP45984IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
5601MK09_HUMANP45984IPR001245Tyr_pkinaseTyrosine protein kinase
5601MK09_HUMANP45984IPR013695WAKWall-associated kinase

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