Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5602
Official Symbol:MAPK10
Other Aliases:FLJ12099|FLJ33785|JNK3|JNK3A|MGC50974|PRKM10|p493F12|p54bSAPK
See related:HGNC:6872|MIM:602897|HPRD:04207
Chromosome:4
Location:4q22.1-q23
Gene Description:mitogen-activated protein kinase 10
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0461
ORGANISM:human
Entrez Gene ID:5602
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25272
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0147
ORGANISM:human
Entrez Gene ID:5602
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:2.17 :: 2.44 :: 1.08 :: 0.98 :: -2.38 :: -2.41 :: -1.21
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
26414CBCerebellum71.2846832275391100.0
26414CTXCerebral cortex100.0100.0
26414HIPHippocampal region100.0100.0
26414HPFHippocampal formation100.0100.0
26414HYHypothalamus87.098693847656287.6718368530273
26414LSXLateral septal complex100.0100.0
26414MBMidbrain100.0100.0
26414MYMedulla95.6754302978516100.0
26414OLFOlfactory bulb100.0100.0
26414PPons88.3069229125977100.0
26414PALPallidum100.0100.0
26414RHPRetrohippocampal region100.0100.0
26414sAMYStriatum-like amygdalar nuclei100.0100.0
26414STRStriatum100.099.1140899658203
26414STRdStriatum dorsal region96.438987731933689.6323547363281
26414STRvStriatum ventral region100.0100.0
26414THThalamus100.0100.0
KARG Evidence 3
KARG ID:HOT0051
Entrez Gene ID:5602
RefSeq ID:NM_138981
Position Information:-, Enhancer, 1218bp
Linkage Marker:rs1202
Evidence Type:ASSOCIATION GENOME SCANNING
Evidence Name:PUBMED
Evidence ID:11704927
Addiction Drug:POLYSUBSTANCE
Addiction Drug Detail:POLYSUBSTANCE ABUSE
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5602GO:0000166IEAFunctionnucleotide binding
5602GO:0004674IEAFunctionprotein serine/threonine kinase activity
5602GO:0004705ISSFunctionJUN kinase activity
5602GO:0004707IEAFunctionMAP kinase activity
5602GO:0004708TASFunctionMAP kinase kinase activity
5602GO:0004713IEAFunctionprotein-tyrosine kinase activity
5602GO:0005524IEAFunctionATP binding
5602GO:0006468IEAProcessprotein amino acid phosphorylation
5602GO:0007165TASProcesssignal transduction
5602GO:0007254ISSProcessJNK cascade
5602GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7157NP_000537.2tumor protein p53HPRD01859
-23162NP_055948.1mitogen-activated protein kinase 8 interacting protein 3 isoform 1HPRD12014
NP_002744.19467NP_004835.1SH3-domain binding protein 5 (BTK-associated) isoform aBIND12933
NP_620448.1--JNKBP1HPRD04207
NP_620448.1--JSAP1HPRD04207
NP_620448.1--SCG10HPRD04207
NP_620448.17157-p53HPRD04207
NP_620448.19467NP_004835.1SH3-domain binding protein 5 (BTK-associated) isoform aHPRD12030
NP_620448.19467NP_004835.1SH3-domain binding protein 5 (BTK-associated) isoform aBIND12934
NP_620448.111221NP_009138.1dual specificity phosphatase 10 isoform aHPRD12320
NP_620448.180824NP_085143.1dual specificity phosphatase 16HPRD09525
NP_620448.180824NP_085143.1dual specificity phosphatase 16HPRD04207
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5602IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
5602IPR008351JNK_MAPKJNK MAP kinase
5602IPR003527MAP_kinMAP kinase
5602IPR000719Prot_kinaseProtein kinase
5602IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
5602IPR001245Tyr_pkinaseTyrosine protein kinase
5602IPR013695WAKWall-associated kinase
5602MK10_HUMANP53779IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
5602MK10_HUMANP53779IPR008351JNK_MAPKJNK MAP kinase
5602MK10_HUMANP53779IPR003527MAP_kinMAP kinase
5602MK10_HUMANP53779IPR000719Prot_kinaseProtein kinase
5602MK10_HUMANP53779IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
5602MK10_HUMANP53779IPR001245Tyr_pkinaseTyrosine protein kinase
5602MK10_HUMANP53779IPR013695WAKWall-associated kinase

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