Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5604
Official Symbol:MAP2K1
Other Aliases:MAPKK1|MEK1|MKK1|PRKMK1
See related:HGNC:6840|MIM:176872|HPRD:01469
Chromosome:15
Location:15q22.1-q22.33
Gene Description:mitogen-activated protein kinase kinase 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0616
ORGANISM:human
Entrez Gene ID:5604
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:170851
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0150
ORGANISM:human
Entrez Gene ID:5604
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:2.46 :: 2.06 :: 1.43 :: 1.01 :: -1.88 :: -2.13 :: -1.91
KARG Evidence 3
KARG ID:EVIL0246
ORGANISM:human
Entrez Gene ID:5604
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15198681
Addiction Drug:OPIOINS
Addiction Drug Detail:Chronic opiate addiction, Downregulations of phosphorylated MEK (85%)
Addiction Brain Area:PFC
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
26395CBCerebellum54.7822875976562100.0
26395CTXCerebral cortex100.0100.0
26395HIPHippocampal region100.0100.0
26395HPFHippocampal formation100.0100.0
26395HYHypothalamus94.0649642944336100.0
26395LSXLateral septal complex100.0100.0
26395MBMidbrain74.055221557617285.0578994750977
26395MYMedulla61.804645538330183.4026947021484
26395OLFOlfactory bulb100.0100.0
26395PPons56.733413696289175.1063232421875
26395PALPallidum77.7805099487305100.0
26395RHPRetrohippocampal region100.0100.0
26395sAMYStriatum-like amygdalar nuclei100.0100.0
26395STRStriatum100.0100.0
26395STRdStriatum dorsal region100.0100.0
26395STRvStriatum ventral region100.0100.0
26395THThalamus64.381919860839872.2026290893555
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5604GO:0000166IEAFunctionnucleotide binding
5604GO:0004674IEAFunctionprotein serine/threonine kinase activity
5604GO:0004708TASFunctionMAP kinase kinase activity
5604GO:0004713IEAFunctionprotein-tyrosine kinase activity
5604GO:0005515IPIFunctionprotein binding
5604GO:0005524IEAFunctionATP binding
5604GO:0006468IEAProcessprotein amino acid phosphorylation
5604GO:0006928TASProcesscell motility
5604GO:0006935TASProcesschemotaxis
5604GO:0007165TASProcesssignal transduction
5604GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5894NP_002871.1v-raf-1 murine leukemia viral oncogene homolog 1HPRD01265
-6196NP_066958.2ribosomal protein S6 kinase, 90kDa, polypeptide 2 isoform aHPRD03403
-8649NP_068805.1mitogen-activated protein kinase kinase 1 interacting protein 1HPRD04485
-7187NP_663777.1TNF receptor-associated factor 3 isoform 1HPRD03539
-283455NP_775869.2kinase suppressor of ras 2HPRD13952
NP_002746.1157310AAK67629.1phosphatidylethanolamine binding proteinHPRD11424
NP_002746.15894NP_002871.1v-raf-1 murine leukemia viral oncogene homolog 1BIND12857
NP_002746.15894NP_002871.1v-raf-1 murine leukemia viral oncogene homolog 1BIND55471
NP_002746.15894NP_002871.1v-raf-1 murine leukemia viral oncogene homolog 1BIND295135
NP_002746.123162NP_055948.1mitogen-activated protein kinase 8 interacting protein 3 isoform 1HPRD12014
NP_002746.1131034NP_570720.1copine IVHPRD05017
NP_002746.1157310NP_659399.1phosphatidylethanolamine-binding protein 4BIND216571
NP_002746.18904NP_690902.1copine IHPRD05014
NP_002746.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5604MP2K1_HUMANQ02750IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
5604MP2K1_HUMANQ02750IPR000719Prot_kinaseProtein kinase
5604MP2K1_HUMANQ02750IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
5604MP2K1_HUMANQ02750IPR001245Tyr_pkinaseTyrosine protein kinase
5604MP2K1_HUMANQ02750IPR013695WAKWall-associated kinase

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