Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5653
Official Symbol:KLK6
Other Aliases:Bssp|Klk7|MGC9355|NEUROSIN|PRSS18|PRSS9|SP59|ZYME|hK6
See related:HGNC:6367|MIM:602652|HPRD:04037
Chromosome:19
Location:19q13.3
Gene Description:kallikrein 6 (neurosin, zyme)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0842
ORGANISM:human
Entrez Gene ID:5653
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-2.1 :: -2 :: -1.5 :: -4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
19144CBCerebellum43.0502929687560.6788501739502
19144CTXCerebral cortex25.688620805740421.9466866254807
19144HIPHippocampal region11.301461637020113.9241209030151
19144HPFHippocampal formation9.9352878928184510.5625413060188
19144HYHypothalamus25.91547298431422.4095234870911
19144LSXLateral septal complex17.951005935668914.4411261081696
19144MBMidbrain37.050410270690936.616042137146
19144MYMedulla71.113004684448273.1761112213135
19144OLFOlfactory bulb28.271875858306927.8007868528366
19144PPons80.997791290283277.1918201446533
19144PALPallidum35.161067008972233.256495475769
19144RHPRetrohippocampal region6.947955071926125.37970691919327
19144sAMYStriatum-like amygdalar nuclei21.797200679779118.2829387187958
19144STRStriatum24.221458435058620.238983631134
19144STRdStriatum dorsal region24.871758460998520.7597818374634
19144STRvStriatum ventral region28.070029735565223.2485908269882
19144THThalamus47.021417617797944.5114011764526
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5653GO:0004252IEAFunctionserine-type endopeptidase activity
5653GO:0004293NASFunctiontissue kallikrein activity
5653GO:0005515IPIFunctionprotein binding
5653GO:0005576IDAComponentextracellular region
5653GO:0005737IDAComponentcytoplasm
5653GO:0006508IEAProcessproteolysis
5653GO:0007417NASProcesscentral nervous system development
5653GO:0008233IEAFunctionpeptidase activity
5653GO:0009611NASProcessresponse to wounding
5653GO:0016540NASProcessprotein autoprocessing
5653GO:0030574NASProcesscollagen catabolism
5653GO:0042246NASProcesstissue regeneration
5653GO:0042445NASProcesshormone metabolism
5653GO:0042552NASProcessmyelination
5653GO:0042982NASProcessamyloid precursor protein metabolism
5653GO:0045595NASProcessregulation of cell differentiation
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5653
5653KLK6_HUMANQ92876IPR001254Peptidase_S1_S6Peptidase S1 and S6, chymotrypsin/Hap
5653KLK6_HUMANQ92876IPR001314Peptidase_S1APeptidase S1A, chymotrypsin
5653KLK6_HUMANQ92876IPR008256Peptidase_S1BPeptidase S1B, glutamyl endopeptidase I

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