Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5654
Official Symbol:HTRA1
Other Aliases:HtrA|L56|ORF480|PRSS11
See related:HGNC:9476|MIM:602194|HPRD:03725
Chromosome:10
Location:10q26.3
Gene Description:HtrA serine peptidase 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0341
ORGANISM:human
Entrez Gene ID:5654
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:56213
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0845
ORGANISM:human
Entrez Gene ID:5654
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.5 :: -1.6 :: -1.9 :: -1.6
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
56213CBCerebellum48.5839462280273100.0
56213CTXCerebral cortex45.78746795654347.0848731994629
56213HIPHippocampal region60.594448089599677.4898147583008
56213HPFHippocampal formation60.272285461425867.9515609741211
56213HYHypothalamus15.648710250854513.0854387283325
56213LSXLateral septal complex53.076911926269546.6853065490723
56213MBMidbrain20.223016738891621.4547691345215
56213MYMedulla41.859554290771553.4409790039062
56213OLFOlfactory bulb77.297149658203188.4154739379883
56213PPons31.85526084899944.4882926940918
56213PALPallidum20.199989318847717.5894203186035
56213RHPRetrohippocampal region58.005764007568450.9740104675293
56213sAMYStriatum-like amygdalar nuclei43.985965728759841.5281982421875
56213STRStriatum41.030395507812543.5391044616699
56213STRdStriatum dorsal region38.355121612548842.7204208374023
56213STRvStriatum ventral region44.36096954345744.984977722168
56213THThalamus15.00041580200214.8282279968262
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5654GO:0001558IEAProcessregulation of cell growth
5654GO:0004252TASFunctionserine-type endopeptidase activity
5654GO:0005520IEAFunctioninsulin-like growth factor binding
5654GO:0005615TASComponentextracellular space
5654GO:0006508IEAProcessproteolysis
5654GO:0008233IEAFunctionpeptidase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5654HTRA1_HUMANQ92743IPR001478PDZPDZ/DHR/GLGF
5654HTRA1_HUMANQ92743IPR001254Peptidase_S1_S6Peptidase S1 and S6, chymotrypsin/Hap
5654HTRA1_HUMANQ92743IPR001314Peptidase_S1APeptidase S1A, chymotrypsin
5654HTRA1_HUMANQ92743IPR001940Peptidase_S1CPeptidase S1C, HrtA/DegP2/Q/S
5654HTRA1_HUMANQ92743IPR008256Peptidase_S1BPeptidase S1B, glutamyl endopeptidase I
5654HTRA1_HUMANQ92743IPR002350Prot_inh_KazalProteinase inhibitor I1, Kazal
5654HTRA1_HUMANQ92743IPR011497Prot_Inh_Kazal_2Protease inhibitor, Kazal-type

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