Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5660
Official Symbol:PSAP
Other Aliases:FLJ00245|GLBA|MGC110993|SAP1
See related:HGNC:9498|MIM:176801|HPRD:01460
Chromosome:10
Location:10q21-q22
Gene Description:prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0068
ORGANISM:human
Entrez Gene ID:5660
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:19156
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
19156CBCerebellum100.0100.0
19156CTXCerebral cortex100.0100.0
19156HIPHippocampal region100.0100.0
19156HPFHippocampal formation100.0100.0
19156HYHypothalamus100.0100.0
19156LSXLateral septal complex100.0100.0
19156MBMidbrain100.0100.0
19156MYMedulla100.0100.0
19156OLFOlfactory bulb100.0100.0
19156PPons100.0100.0
19156PALPallidum100.0100.0
19156RHPRetrohippocampal region100.0100.0
19156sAMYStriatum-like amygdalar nuclei100.0100.0
19156STRStriatum100.0100.0
19156STRdStriatum dorsal region100.0100.0
19156STRvStriatum ventral region100.0100.0
19156THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5660GO:0005615TASComponentextracellular space
5660GO:0005764IEAComponentlysosome
5660GO:0006629IEAProcesslipid metabolism
5660GO:0006665IEAProcesssphingolipid metabolism
5660GO:0006687TASProcessglycosphingolipid metabolism
5660GO:0006869TASProcesslipid transport
5660GO:0007040IEAProcesslysosome organization and biogenesis
5660GO:0008047TASFunctionenzyme activator activity
5660GO:0008289TASFunctionlipid binding
5660GO:0016021TASComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_002769.123621NP_036236.1beta-site APP-cleaving enzyme 1 isoform A preproproteinBIND262675
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5660SAP_HUMANP07602IPR003119SapASaposin type A
5660SAP_HUMANP07602IPR007856SapB_1Saposin-like type B, 1
5660SAP_HUMANP07602IPR008138SapB_2Saposin-like type B, 2
5660SAP_HUMANP07602IPR008373SaposinSaposin
5660SAP_HUMANP07602IPR008139SaposinBSaposin B

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