Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5690
Official Symbol:PSMB2
Other Aliases:HC7-I|MGC104215|MGC126885
See related:HGNC:9539|MIM:602175|HPRD:03708
Chromosome:1
Location:1p34.2
Gene Description:proteasome (prosome, macropain) subunit, beta type, 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0256
ORGANISM:human
Entrez Gene ID:5690
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Downregulated
Fold Change:-0.56
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
26445CBCerebellum13.601482868194616.8702874183655
26445CTXCerebral cortex20.703633308410611.7446303367615
26445HIPHippocampal region26.019932746887229.32359790802
26445HPFHippocampal formation26.140009880065922.0882749557495
26445HYHypothalamus3.987530231475832.21485465764999
26445LSXLateral septal complex2.169692933559421.18544912338257
26445MBMidbrain6.091015577316284.68610537052155
26445MYMedulla20.217840671539318.4693183898926
26445OLFOlfactory bulb20.581277370452910.7987971305847
26445PPons16.041825771331813.6112408638
26445PALPallidum4.503796458244322.60818386077881
26445RHPRetrohippocampal region26.563116073608414.1892833709717
26445sAMYStriatum-like amygdalar nuclei2.767728388309481.15499022603035
26445STRStriatum3.78382146358492.43347495794296
26445STRdStriatum dorsal region3.905471205711362.76294904947281
26445STRvStriatum ventral region4.384261608123782.29299783706665
26445THThalamus9.860388755798346.1630494594574
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5690GO:0004298IEAFunctionthreonine endopeptidase activity
5690GO:0005634IEAComponentnucleus
5690GO:0005829IEAComponentcytosol
5690GO:0005839IEAComponentproteasome core complex (sensu Eukaryota)
5690GO:0006511IEAProcessubiquitin-dependent protein catabolism
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_002785.1155459NP_057851.1Vif--
NP_002785.1155871NP_057853.1Tat--
NP_002785.1155871NP_057853.1Tat--
NP_002785.1155871NP_057853.1Tat--
NP_002785.1155871NP_057853.1Tat--
NP_002785.1155871NP_057853.1TatBIND145548
NP_002785.1155348NP_705928.1integrase--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5690PSB2_HUMANP49721IPR000243Pept_T1A_subBPeptidase T1A, proteasome beta-subunit
5690PSB2_HUMANP49721IPR001353Proteasome_A_B20S proteasome, A and B subunits

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