Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5692
Official Symbol:PSMB4
Other Aliases:HN3|HsN3|PROS26
See related:HGNC:9541|MIM:602177|HPRD:03710
Chromosome:1
Location:1q21
Gene Description:proteasome (prosome, macropain) subunit, beta type, 4
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0474
ORGANISM:human
Entrez Gene ID:5692
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:58854
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
19172CBCerebellum27.261068344116261.9881858825684
19172CTXCerebral cortex100.0100.0
19172HIPHippocampal region100.0100.0
19172HPFHippocampal formation100.0100.0
19172HYHypothalamus88.8747177124023100.0
19172LSXLateral septal complex85.587356567382880.1252822875977
19172MBMidbrain62.765659332275478.9843902587891
19172MYMedulla47.145786285400486.4280014038086
19172OLFOlfactory bulb97.4430465698242100.0
19172PPons52.422985076904383.5111236572266
19172PALPallidum64.207206726074274.6696472167969
19172RHPRetrohippocampal region100.0100.0
19172sAMYStriatum-like amygdalar nuclei78.527427673339879.297004699707
19172STRStriatum51.420024871826247.3899421691895
19172STRdStriatum dorsal region44.012683868408240.4464492797852
19172STRvStriatum ventral region54.115459442138746.6325531005859
19172THThalamus75.074058532714884.269905090332
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5692GO:0004298IEAFunctionthreonine endopeptidase activity
5692GO:0005634TASComponentnucleus
5692GO:0005829IEAComponentcytosol
5692GO:0005839IEAComponentproteasome core complex (sensu Eukaryota)
5692GO:0006511IEAProcessubiquitin-dependent protein catabolism
5692GO:0043234IEAComponentprotein complex
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_002787.2155459NP_057851.1Vif--
NP_002787.2155871NP_057853.1Tat--
NP_002787.2155871NP_057853.1Tat--
NP_002787.2155871NP_057853.1Tat--
NP_002787.2155871NP_057853.1Tat--
NP_002787.2155348NP_705928.1integrase--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5692PSB4_HUMANP28070IPR000243Pept_T1A_subBPeptidase T1A, proteasome beta-subunit
5692PSB4_HUMANP28070IPR001353Proteasome_A_B20S proteasome, A and B subunits

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