Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5694
Official Symbol:PSMB6
Other Aliases:DELTA|LMPY|MGC5169|Y
See related:HGNC:9543|MIM:600307|HPRD:02630
Chromosome:17
Location:17p13
Gene Description:proteasome (prosome, macropain) subunit, beta type, 6
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0313
ORGANISM:human
Entrez Gene ID:5694
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.58
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
19175CBCerebellum41.658176422119165.0684051513672
19175CTXCerebral cortex100.0100.0
19175HIPHippocampal region51.154869079589895.8910369873047
19175HPFHippocampal formation53.827816009521576.6756057739258
19175HYHypothalamus48.556472778320346.9147453308105
19175LSXLateral septal complex78.010749816894565.5747222900391
19175MBMidbrain54.544708251953158.4428482055664
19175MYMedulla70.839118957519596.9897842407227
19175OLFOlfactory bulb89.059593200683689.3278579711914
19175PPons56.452316284179772.492805480957
19175PALPallidum74.470802307128985.3014450073242
19175RHPRetrohippocampal region57.707904815673855.7956466674805
19175sAMYStriatum-like amygdalar nuclei73.390663146972764.2045745849609
19175STRStriatum100.086.1443710327148
19175STRdStriatum dorsal region100.091.9203109741211
19175STRvStriatum ventral region94.99329376220777.7425003051758
19175THThalamus56.472179412841856.3597183227539
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5694GO:0004298IEAFunctionthreonine endopeptidase activity
5694GO:0005829IEAComponentcytosol
5694GO:0005839NASComponentproteasome core complex (sensu Eukaryota)
5694GO:0006511NASProcessubiquitin-dependent protein catabolism
5694GO:0043234IEAComponentprotein complex
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_002789.1155459NP_057851.1Vif--
NP_002789.1155871NP_057853.1Tat--
NP_002789.1155871NP_057853.1Tat--
NP_002789.1155871NP_057853.1Tat--
NP_002789.1155871NP_057853.1Tat--
NP_002789.1155871NP_057853.1TatBIND145546
NP_002789.1155348NP_705928.1integrase--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5694PSB6_HUMANP28072IPR000243Pept_T1A_subBPeptidase T1A, proteasome beta-subunit
5694PSB6_HUMANP28072IPR001353Proteasome_A_B20S proteasome, A and B subunits

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