Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5695
Official Symbol:PSMB7
Other Aliases:Z
See related:HGNC:9544|MIM:604030|HPRD:04940
Chromosome:9
Location:9q34.11-q34.12
Gene Description:proteasome (prosome, macropain) subunit, beta type, 7
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0941
ORGANISM:human
Entrez Gene ID:5695
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.7 :: -1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
19177CBCerebellum44.0302734375100.0
19177CTXCerebral cortex100.0100.0
19177HIPHippocampal region100.0100.0
19177HPFHippocampal formation100.0100.0
19177HYHypothalamus89.87683868408299.383659362793
19177LSXLateral septal complex100.0100.0
19177MBMidbrain100.0100.0
19177MYMedulla96.035774230957100.0
19177OLFOlfactory bulb100.0100.0
19177PPons90.9934310913086100.0
19177PALPallidum87.5625076293945100.0
19177RHPRetrohippocampal region100.0100.0
19177sAMYStriatum-like amygdalar nuclei100.0100.0
19177STRStriatum98.78881835937591.1534957885742
19177STRdStriatum dorsal region98.263702392578188.5271911621094
19177STRvStriatum ventral region93.797546386718884.8949127197266
19177THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5695GO:0004298IEAFunctionthreonine endopeptidase activity
5695GO:0005829IEAComponentcytosol
5695GO:0005839IEAComponentproteasome core complex (sensu Eukaryota)
5695GO:0006511IEAProcessubiquitin-dependent protein catabolism
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_002790.1155459NP_057851.1Vif--
NP_002790.1155871NP_057853.1Tat--
NP_002790.1155871NP_057853.1Tat--
NP_002790.1155871NP_057853.1Tat--
NP_002790.1155871NP_057853.1Tat--
NP_002790.1155871NP_057853.1TatBIND145545
NP_002790.1155348NP_705928.1integrase--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5695PSB7_HUMANQ99436IPR006034Asp/GlutamnseAsparaginase/glutaminase
5695PSB7_HUMANQ99436IPR000243Pept_T1A_subBPeptidase T1A, proteasome beta-subunit
5695PSB7_HUMANQ99436IPR001353Proteasome_A_B20S proteasome, A and B subunits

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