Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5724
Official Symbol:PTAFR
Other Aliases:PAFR
See related:HGNC:9582|MIM:173393|HPRD:01422
Chromosome:1
Location:1p35-p34.3
Gene Description:platelet-activating factor receptor
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0933
ORGANISM:human
Entrez Gene ID:5724
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.6 :: 2.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
19204CBCerebellum0.00.0
19204CTXCerebral cortex0.00.0
19204HIPHippocampal region0.00.0
19204HPFHippocampal formation0.00.0
19204HYHypothalamus0.00.0
19204LSXLateral septal complex0.00.0
19204MBMidbrain0.00.0
19204MYMedulla0.00.0
19204OLFOlfactory bulb0.00.0
19204PPons0.00.0
19204PALPallidum0.00.0
19204RHPRetrohippocampal region0.00.0
19204sAMYStriatum-like amygdalar nuclei0.00.0
19204STRStriatum0.00.0
19204STRdStriatum dorsal region0.00.0
19204STRvStriatum ventral region0.00.0
19204THThalamus0.00.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5724GO:0004872IEAFunctionreceptor activity
5724GO:0004992IDAFunctionplatelet activating factor receptor activity
5724GO:0005543IDAFunctionphospholipid binding
5724GO:0005887TASComponentintegral to plasma membrane
5724GO:0006935TASProcesschemotaxis
5724GO:0006954TASProcessinflammatory response
5724GO:0007165IEAProcesssignal transduction
5724GO:0007186IMPProcessG-protein coupled receptor protein signaling pathway
5724GO:0016020IDAComponentmembrane
5724GO:0019735TASProcessantimicrobial humoral response (sensu Vertebrata)
5724GO:0048015IDAProcessphosphoinositide-mediated signaling
5724GO:0050896IEAProcessresponse to stimulus
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5999NP_005604.1regulator of G-protein signaling 4HPRD03947
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5724PTAFR_HUMANP25105IPR000248Angtn2_rcptAngiotensin II receptor
5724PTAFR_HUMANP25105IPR000496Brdyknn_rcptBradykinin receptor
5724PTAFR_HUMANP25105IPR000355Chmkine_rcptChemokine receptor
5724PTAFR_HUMANP25105IPR001277CXC_4_rcptC-X-C chemokine receptor, type 4
5724PTAFR_HUMANP25105IPR004071Cyst_leuk_rcptCysteinyl leukotriene receptor
5724PTAFR_HUMANP25105IPR005384Duffy_cmk_rcptDuffy antigen/chemokine receptor
5724PTAFR_HUMANP25105IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
5724PTAFR_HUMANP25105IPR002286P2_purnocptorP2 purinoceptor
5724PTAFR_HUMANP25105IPR002282PAF_rcptPlatelet-activating factor receptor
5724PTAFR_HUMANP25105IPR003912Protea_act_rcptProtease-activated receptor

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