Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5728
Official Symbol:PTEN
Other Aliases:BZS|MGC11227|MHAM|MMAC1|PTEN1|TEP1
See related:HGNC:9588|MIM:601728|HPRD:03431
Chromosome:10
Location:10q23.3
Gene Description:phosphatase and tensin homolog (mutated in multiple advanced cancers 1)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0182
ORGANISM:human
Entrez Gene ID:5728
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:19211
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5728GO:0000079TASProcessregulation of cyclin dependent protein kinase activity
5728GO:0004438IDAFunctionphosphatidylinositol-3-phosphatase activity
5728GO:0004722IDAFunctionprotein serine/threonine phosphatase activity
5728GO:0004725IDAFunctionprotein tyrosine phosphatase activity
5728GO:0005515IPIFunctionprotein binding
5728GO:0005737IDAComponentcytoplasm
5728GO:0005737TASComponentcytoplasm
5728GO:0006470IDAProcessprotein amino acid dephosphorylation
5728GO:0006470TASProcessprotein amino acid dephosphorylation
5728GO:0006917ISSProcessinduction of apoptosis
5728GO:0007049IEAProcesscell cycle
5728GO:0007417ISSProcesscentral nervous system development
5728GO:0007507ISSProcessheart development
5728GO:0008138IEAFunctionprotein tyrosine/serine/threonine phosphatase activity
5728GO:0008283TASProcesscell proliferation
5728GO:0008285IMPProcessnegative regulation of cell proliferation
5728GO:0016314IDAFunctionphosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
5728GO:0016477ISSProcesscell migration
5728GO:0016787IEAFunctionhydrolase activity
5728GO:0030165IPIFunctionPDZ domain binding
5728GO:0030336IMPProcessnegative regulation of cell migration
5728GO:0031647IMPProcessregulation of protein stability
5728GO:0045786IEAProcessnegative regulation of progression through cell cycle
5728GO:0046855IDAProcessinositol phosphate dephosphorylation
5728GO:0046856IDAProcessphosphoinositide dephosphorylation
5728GO:0051717IDAFunctioninositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
5728GO:0051800IDAFunctionphosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
5728GO:0051895IMPProcessnegative regulation of focal adhesion formation
5728GO:0051898IMPProcessnegative regulation of protein kinase B signaling cascade
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5829BAA18998.1paxillin gammaHPRD03937
-7157NP_000537.2tumor protein p53HPRD01859
-7332NP_003338.1ubiquitin-conjugating enzyme E2L 3 isoform 1HPRD04762
NP_000305.1--MAGI-2HPRD03431
NP_000305.1--CK2HPRD03431
NP_000305.1--UbC9HPRD03431
NP_000305.15829-PaxillinHPRD03431
NP_000305.17157-p53HPRD03431
NP_000305.17332-Ubiquitin conjugating enzyme E2L3HPRD03431
NP_000305.15747NP_005598.3PTK2 protein tyrosine kinase 2 isoform bHPRD03431
NP_000305.15747NP_005598.3PTK2 protein tyrosine kinase 2 isoform bHPRD02859
NP_000305.19863NP_036433.2membrane associated guanylate kinase, WW and PDZ domain containing 2HPRD16212
NP_000305.19961NP_059447.2major vault proteinHPRD03431
NP_000305.19961NP_059447.2major vault proteinHPRD05475
NP_000305.1260425NP_066016.1membrane-associated guanylate kinase-related 3 isoform 1HPRD11290
NP_000305.26093NP_005397.1Rho-associated, coiled-coil containing protein kinase 1BIND214947
NP_000305.229997NP_056525.1glioma tumor suppressor candidate region gene 2BIND216573
NP_000305.2260425NP_066016.1membrane-associated guanylate kinase-related 3 isoform 1BIND214319
NP_000305.2155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5728PTEN_HUMANP60484IPR000340DS_phosphataseDual specificity protein phosphatase
5728PTEN_HUMANP60484IPR000387TYR_phosphataseTyrosine specific protein phosphatase and dual specificity protein phosphatase

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