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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry

For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information Gene ID: 5728 Official Symbol: PTEN Other Aliases: BZS|MGC11227|MHAM|MMAC1|PTEN1|TEP1 See related: HGNC:9588|MIM:601728|HPRD:03431 Chromosome: 10 Location: 10q23.3 Gene Description: phosphatase and tensin homolog (mutated in multiple advanced cancers 1) Gene type: protein-coding Gene Structure: Genomic Context: KARG Evidence 1 KARG ID: EVIC0182 ORGANISM: human Entrez Gene ID: 5728 Evidence Type: Mapping from mouse Evidence ID Type: Entrez Gene Evidence ID: 19211 Addiction Drug: Addiction Drug Detail: Addiction Brain Area: Drug Effects: Fold Change: Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas) Mouse Entrez Gene ID Brain Region Brain Region Detail Expression Level Expression Density Gene Ontology Gene ID GO ID Evidence GO Type GO Description 5728 GO:0000079 TAS Process regulation of cyclin dependent protein kinase activity 5728 GO:0004438 IDA Function phosphatidylinositol-3-phosphatase activity 5728 GO:0004722 IDA Function protein serine/threonine phosphatase activity 5728 GO:0004725 IDA Function protein tyrosine phosphatase activity 5728 GO:0005515 IPI Function protein binding 5728 GO:0005737 IDA Component cytoplasm 5728 GO:0005737 TAS Component cytoplasm 5728 GO:0006470 IDA Process protein amino acid dephosphorylation 5728 GO:0006470 TAS Process protein amino acid dephosphorylation 5728 GO:0006917 ISS Process induction of apoptosis 5728 GO:0007049 IEA Process cell cycle 5728 GO:0007417 ISS Process central nervous system development 5728 GO:0007507 ISS Process heart development 5728 GO:0008138 IEA Function protein tyrosine/serine/threonine phosphatase activity 5728 GO:0008283 TAS Process cell proliferation 5728 GO:0008285 IMP Process negative regulation of cell proliferation 5728 GO:0016314 IDA Function phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity 5728 GO:0016477 ISS Process cell migration 5728 GO:0016787 IEA Function hydrolase activity 5728 GO:0030165 IPI Function PDZ domain binding 5728 GO:0030336 IMP Process negative regulation of cell migration 5728 GO:0031647 IMP Process regulation of protein stability 5728 GO:0045786 IEA Process negative regulation of progression through cell cycle 5728 GO:0046855 IDA Process inositol phosphate dephosphorylation 5728 GO:0046856 IDA Process phosphoinositide dephosphorylation 5728 GO:0051717 IDA Function inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity 5728 GO:0051800 IDA Function phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity 5728 GO:0051895 IMP Process negative regulation of focal adhesion formation 5728 GO:0051898 IMP Process negative regulation of protein kinase B signaling cascade Interaction Information Gene Product ID Interactant Gene ID Interactant Gene Product ID Interactant Gene Product Name Source Source ID - 5829 BAA18998.1 paxillin gamma HPRD 03937 - 7157 NP_000537.2 tumor protein p53 HPRD 01859 - 7332 NP_003338.1 ubiquitin-conjugating enzyme E2L 3 isoform 1 HPRD 04762 NP_000305.1 - - MAGI-2 HPRD 03431 NP_000305.1 - - CK2 HPRD 03431 NP_000305.1 - - UbC9 HPRD 03431 NP_000305.1 5829 - Paxillin HPRD 03431 NP_000305.1 7157 - p53 HPRD 03431 NP_000305.1 7332 - Ubiquitin conjugating enzyme E2L3 HPRD 03431 NP_000305.1 5747 NP_005598.3 PTK2 protein tyrosine kinase 2 isoform b HPRD 03431 NP_000305.1 5747 NP_005598.3 PTK2 protein tyrosine kinase 2 isoform b HPRD 02859 NP_000305.1 9863 NP_036433.2 membrane associated guanylate kinase, WW and PDZ domain containing 2 HPRD 16212 NP_000305.1 9961 NP_059447.2 major vault protein HPRD 03431 NP_000305.1 9961 NP_059447.2 major vault protein HPRD 05475 NP_000305.1 260425 NP_066016.1 membrane-associated guanylate kinase-related 3 isoform 1 HPRD 11290 NP_000305.2 6093 NP_005397.1 Rho-associated, coiled-coil containing protein kinase 1 BIND 214947 NP_000305.2 29997 NP_056525.1 glioma tumor suppressor candidate region gene 2 BIND 216573 NP_000305.2 260425 NP_066016.1 membrane-associated guanylate kinase-related 3 isoform 1 BIND 214319 NP_000305.2 155871 NP_057853.1 Tat - - Domain Information Gene ID Uniprot/Swissprot ID Uniprot/Swissprot ACC Interpro ID Interpro Short Description Interpro Long Description 5728 PTEN_HUMAN P60484 IPR000340 DS_phosphatase Dual specificity protein phosphatase 5728 PTEN_HUMAN P60484 IPR000387 TYR_phosphatase Tyrosine specific protein phosphatase and dual specificity protein phosphatase © Center for Bioinformatics(CBI), Peking University Any Comments and suggestions to : KARG GROUP.