Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5730
Official Symbol:PTGDS
Other Aliases:PDS|PGD2|PGDS|PGDS2
See related:HGNC:9592|MIM:176803|HPRD:08904
Chromosome:9
Location:9q34.2-q34.3
Gene Description:prostaglandin D2 synthase 21kDa (brain)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0954
ORGANISM:human
Entrez Gene ID:5730
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-2 :: -2.2
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
19215CBCerebellum75.921221923828199.6898162841797
19215CTXCerebral cortex66.809608459472779.4779624938965
19215HIPHippocampal region60.273845672607488.7238876342773
19215HPFHippocampal formation68.224417114257888.314909362793
19215HYHypothalamus91.391448974609494.8115646362305
19215LSXLateral septal complex80.317052459716884.8746520996094
19215MBMidbrain100.0100.0
19215MYMedulla100.0100.0
19215OLFOlfactory bulb63.958011627197376.2829170227051
19215PPons100.0100.0
19215PALPallidum98.801861572265698.7203140258789
19215RHPRetrohippocampal region81.134233856201288.5259323120117
19215sAMYStriatum-like amygdalar nuclei70.396931457519584.6650779724121
19215STRStriatum68.559862518310678.781095123291
19215STRdStriatum dorsal region68.861698913574278.8598266601562
19215STRvStriatum ventral region59.712615203857467.2296352386475
19215THThalamus98.11489257812599.1721038818359
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5730GO:0001516ISSProcessprostaglandin biosynthesis
5730GO:0004667ISSFunctionprostaglandin-D synthase activity
5730GO:0005215ISSFunctiontransporter activity
5730GO:0005488IEAFunctionbinding
5730GO:0005501ISSFunctionretinoid binding
5730GO:0005576IDAComponentextracellular region
5730GO:0005635ISSComponentnuclear envelope
5730GO:0005791IDAComponentrough endoplasmic reticulum
5730GO:0005795IEAComponentGolgi stack
5730GO:0006633IEAProcessfatty acid biosynthesis
5730GO:0006810ISSProcesstransport
5730GO:0016020IEAComponentmembrane
5730GO:0016853IEAFunctionisomerase activity
5730GO:0045187ISSProcessregulation of circadian sleep/wake cycle, sleep
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5730PTGDS_HUMANP41222IPR002968A1-microgloblnAlpha-1-microglobulin
5730PTGDS_HUMANP41222IPR002969ApolipopDApolipoprotein D
5730PTGDS_HUMANP41222IPR002447BlactoglobulinBeta-lactoglobulin
5730PTGDS_HUMANP41222IPR002345LipocalinLipocalin
5730PTGDS_HUMANP41222IPR000566Lipocln_cytFABPLipocalin-related protein and Bos/Can/Equ allergen
5730PTGDS_HUMANP41222IPR002971Maj_urinaryMus/Rat 1 allergen
5730PTGDS_HUMANP41222IPR003087N_gelatinaseNeutrophil gelatinase-associated lipocalin
5730PTGDS_HUMANP41222IPR002972PstgldnD_synthProstaglandin D synthase
5730PTGDS_HUMANP41222IPR002449Retinol_bdRetinol-binding protein
5730PTGDS_HUMANP41222IPR002450vonEbner_glandvon Ebner's gland protein/ Bos/Can allergen

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