Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5747
Official Symbol:PTK2
Other Aliases:FADK|FAK|FAK1|pp125FAK
See related:HGNC:9611|MIM:600758|HPRD:02859
Chromosome:8
Location:8q24-qter
Gene Description:PTK2 protein tyrosine kinase 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0148
ORGANISM:human
Entrez Gene ID:5747
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:1.52 :: 2.18 :: 1.92 :: -1.02 :: -0.64 :: -0.87 :: -3.39
KARG Evidence 2
KARG ID:QTL0216
ORGANISM:human
Entrez Gene ID:5747
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
14083CBCerebellum8.749001085758216.6540607213974
14083CTXCerebral cortex32.995980739593511.725802898407
14083HIPHippocampal region16.396996974945110.402197599411
14083HPFHippocampal formation17.95407783985148.68771803379059
14083HYHypothalamus1.388355590403080.586406739428639
14083LSXLateral septal complex3.500751495361331.53936314582825
14083MBMidbrain2.223195999860761.10851411521435
14083MYMedulla3.316138491034511.65073324739933
14083OLFOlfactory bulb18.65307241678246.0947750210762
14083PPons2.984729409217831.48648503422737
14083PALPallidum2.319077879190440.87512369081378
14083RHPRetrohippocampal region19.89789712429057.13508266210556
14083sAMYStriatum-like amygdalar nuclei2.506608203053471.02893175184727
14083STRStriatum5.837677776813512.57273811101913
14083STRdStriatum dorsal region5.747459530830382.4357847571373
14083STRvStriatum ventral region8.812133923172954.38649132847786
14083THThalamus2.963058710098271.68795049190521
KARG Evidence 3
KARG ID:QTL0216
Trait:alcohol consumption
Peak:42
Peak Marker:D15Mit105
Parents:C57BL/6ByJ x BALB/c intercross
Evidence ID:11109025
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5747GO:0000166IEAFunctionnucleotide binding
5747GO:0004713IEAFunctionprotein-tyrosine kinase activity
5747GO:0004713TASFunctionprotein-tyrosine kinase activity
5747GO:0005488IEAFunctionbinding
5747GO:0005515IPIFunctionprotein binding
5747GO:0005524IEAFunctionATP binding
5747GO:0005856IEAComponentcytoskeleton
5747GO:0005856TASComponentcytoskeleton
5747GO:0006468ICProcessprotein amino acid phosphorylation
5747GO:0006468IEAProcessprotein amino acid phosphorylation
5747GO:0007229TASProcessintegrin-mediated signaling pathway
5747GO:0016740IEAFunctiontransferase activity
5747GO:0042169IPIFunctionSH2 domain binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5829BAA18998.1paxillin gammaHPRD03937
-6401NP_000441.1selectin E precursorHPRD00566
-5794NP_002833.1protein tyrosine phosphatase, receptor type, H precursorHPRD03942
-5829NP_002850.1paxillinBIND185075
-6850NP_003168.2spleen tyrosine kinaseHPRD02514
-7205NP_003293.1thyroid hormone receptor interactor 6HPRD04242
-7430NP_003370.2villin 2HPRD00475
-8440NP_003572.1NCK adaptor protein 2HPRD05378
-6714NP_005408.1proto-oncogene tyrosine-protein kinase SRCHPRD01819
-7094NP_006280.2talin 1HPRD01726
-10519NP_006375.1calcium and integrin binding 1 (calmyrin)HPRD03800
-6772NP_009330.1signal transducer and activator of transcription 1 isoform alphaHPRD02777
-28964NP_054749.1G protein-coupled receptor kinase-interactor 1HPRD06577
-9564NP_055382.1breast cancer anti-estrogen resistance 1HPRD04248
-23092NP_055886.1GTPase regulator associated with the focal adhesion kinase pp125HPRD05643
-7041NP_057011.2androgen receptor coactivator ARA55HPRD03831
-50807NP_060952.1development and differentiation enhancing factor 1HPRD05809
-64780NP_073602.2microtubule associated monoxygenase, calponin and LIM domain containing 1HPRD06183
NP_005598.3--pp200HPRD02859
NP_005598.3--FIP200HPRD02859
NP_005598.3--Protein phosphatase-1HPRD02859
NP_005598.3--MAPK8IP3HPRD02859
NP_005598.39564-CRK associated substrateHPRD02859
NP_005598.36714-c-SrcHPRD02859
NP_005598.37094-TalinHPRD02859
NP_005598.36401-Selectin EHPRD02859
NP_005598.323092-GTPase regulator associated with focal adhesion kinaseHPRD02859
NP_005598.35829-PaxillinHPRD02859
NP_005598.36850-SYKHPRD02859
NP_005598.37041-HIC5HPRD02859
NP_005598.310580-CBL associated proteinHPRD02859
NP_005598.310278-Embryonal Fyn associated substrateHPRD02859
NP_005598.39821-RB1 inducible coiled coil 1HPRD02859
NP_005598.364780-CasL interacting moleculeHPRD02859
NP_005598.328964-GIT1HPRD02859
NP_005598.35794-Protein tyrosine phosphatase receptor type HHPRD02859
NP_005598.36772-STAT1HPRD02859
NP_005598.37430-EzrinHPRD02859
NP_005598.39564-p130CASHPRD02859
NP_005598.38440-Grb4HPRD02859
NP_005598.350807-ASAP1HPRD02859
NP_005598.310519-Calcium and integrin binding proteinHPRD02859
NP_005598.37205-Thyroid hormone receptor interactor 6HPRD02859
NP_005598.35781NP_002825.2protein tyrosine phosphatase, non-receptor type 11 isoform 1HPRD02859
NP_005598.35782NP_002826.2protein tyrosine phosphatase, non-receptor type 12HPRD02859
NP_005598.35782NP_002826.2protein tyrosine phosphatase, non-receptor type 12HPRD02513
NP_005598.36714NP_005408.1proto-oncogene tyrosine-protein kinase SRCBIND57959
NP_005598.36714NP_005408.1proto-oncogene tyrosine-protein kinase SRCHPRD02859
NP_005598.35747NP_005598.3PTK2 protein tyrosine kinase 2 isoform bHPRD02859
NP_005598.38554NP_057250.1protein inhibitor of activated STAT, 1HPRD02859
NP_005598.38554NP_057250.1protein inhibitor of activated STAT, 1HPRD16029
NP_005598.36464NP_892113.1SHC (Src homology 2 domain containing) transforming protein 1HPRD02859
NP_005598.36464NP_892113.1SHC (Src homology 2 domain containing) transforming protein 1HPRD02780
NP_722560.16464--BIND196988
NP_722560.18737NP_003795.1receptor (TNFRSF)-interacting serine-threonine kinase 1BIND183014
NP_722560.16714NP_005408.1proto-oncogene tyrosine-protein kinase SRCBIND196985
NP_722560.19564NP_055382.2breast cancer anti-estrogen resistance 1BIND196989
NP_722560.15747NP_722560.1PTK2 protein tyrosine kinase 2 isoform aBIND199991
NP_722560.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5747FAK1_HUMANQ05397IPR000299Band_4.1Band 4.1
5747FAK1_HUMANQ05397IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
5747FAK1_HUMANQ05397IPR005189Focal_ATFocal adhesion targeting region
5747FAK1_HUMANQ05397IPR000719Prot_kinaseProtein kinase
5747FAK1_HUMANQ05397IPR001245Tyr_pkinaseTyrosine protein kinase
5747FAK1_HUMANQ05397IPR008266Tyr_pkinase_ASTyrosine protein kinase, active site
5747FAK1_HUMANQ05397IPR013695WAKWall-associated kinase

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