Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5764
Official Symbol:PTN
Other Aliases:HARP|HBGF8|HBNF|NEGF1
See related:HGNC:9630|MIM:162095|HPRD:01199
Chromosome:7
Location:7q33-q34
Gene Description:pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0111
ORGANISM:human
Entrez Gene ID:5764
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:1.48 :: 2.05 :: -0.22 :: 1.71 :: -1.95 :: -2.31 :: 0.03
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
19242CBCerebellum100.0100.0
19242CTXCerebral cortex100.0100.0
19242HIPHippocampal region100.0100.0
19242HPFHippocampal formation100.0100.0
19242HYHypothalamus98.076580047607483.870979309082
19242LSXLateral septal complex100.0100.0
19242MBMidbrain100.097.0669593811035
19242MYMedulla97.719642639160296.931037902832
19242OLFOlfactory bulb100.0100.0
19242PPons100.0100.0
19242PALPallidum100.099.3367576599121
19242RHPRetrohippocampal region100.0100.0
19242sAMYStriatum-like amygdalar nuclei100.096.2730102539062
19242STRStriatum100.0100.0
19242STRdStriatum dorsal region100.0100.0
19242STRvStriatum ventral region100.098.4190254211426
19242THThalamus100.098.5477714538574
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5764GO:0000074IEAProcessregulation of progression through cell cycle
5764GO:0004864TASFunctionprotein phosphatase inhibitor activity
5764GO:0005125NRFunctioncytokine activity
5764GO:0005615TASComponentextracellular space
5764GO:0007185TASProcesstransmembrane receptor protein tyrosine phosphatase signaling pathway
5764GO:0007399TASProcessnervous system development
5764GO:0008083IEAFunctiongrowth factor activity
5764GO:0008201IEAFunctionheparin binding
5764GO:0008283IEAProcesscell proliferation
5764GO:0008284TASProcesspositive regulation of cell proliferation
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6382NP_002988.3syndecan 1 precursorHPRD01718
-9672NP_055469.1syndecan 3HPRD01719
NP_002816.16382-Syndecan 1HPRD01199
NP_002816.19672-Syndecan 3HPRD01199
NP_002816.15787-Receptor type protein tyrosine phosphatase betaHPRD01199
NP_002816.15803-Protein tyrosine phosphatase, receptor zeta 1HPRD01199
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5764PTN_HUMANP21246IPR000762PTN_MK_hepar_bdPTN/MK heparin-binding protein

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