Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5786
Official Symbol:PTPRA
Other Aliases:HEPTP|HLPR|HPTPA|HPTPalpha|LRP|PTPA|PTPRL2|R-PTP-alpha|RPTPA
See related:HGNC:9664|MIM:176884|HPRD:01476
Chromosome:20
Location:20p13
Gene Description:protein tyrosine phosphatase, receptor type, A
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0143
ORGANISM:human
Entrez Gene ID:5786
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:2.47 :: 1.94 :: 0.13 :: 0.41 :: -2.45 :: -2.39 :: -1.23
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
80743CBCerebellum3.699434757232674.59024953842163
80743CTXCerebral cortex5.979507446289064.72547721862793
80743HIPHippocampal region18.360412597656222.0886325836182
80743HPFHippocampal formation15.428799629211416.7214660644531
80743HYHypothalamus2.445276737213132.51762986183167
80743LSXLateral septal complex2.208899021148681.68165326118469
80743MBMidbrain0.9889506697654721.59829604625702
80743MYMedulla5.948378086090098.11541366577148
80743OLFOlfactory bulb17.515302658081113.5735664367676
80743PPons4.089908123016366.02600908279419
80743PALPallidum3.460466623306273.22437024116516
80743RHPRetrohippocampal region8.427005767822276.91765642166138
80743sAMYStriatum-like amygdalar nuclei7.587346076965335.25641202926636
80743STRStriatum3.781730413436892.87482023239136
80743STRdStriatum dorsal region1.904032111167911.47332167625427
80743STRvStriatum ventral region8.714134216308596.39772701263428
80743THThalamus2.214546203613282.13858246803284
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5786GO:0004872IEAFunctionreceptor activity
5786GO:0005001TASFunctiontransmembrane receptor protein tyrosine phosphatase activity
5786GO:0005887TASComponentintegral to plasma membrane
5786GO:0006470IEAProcessprotein amino acid dephosphorylation
5786GO:0016020IEAComponentmembrane
5786GO:0016787IEAFunctionhydrolase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_002827.15789NP_002830.1protein tyrosine phosphatase, receptor type, D isoform 1 precursorHPRD03358
NP_002827.15792NP_002831.1protein tyrosine phosphatase, receptor type, F isoform 1 precursorHPRD01552
NP_543030.15786NP_543030.1protein tyrosine phosphatase, receptor type, A isoform 2 precursorBIND201912
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5786IPR000387TYR_phosphataseTyrosine specific protein phosphatase and dual specificity protein phosphatase
5786IPR000242Tyr_PPTyrosine specific protein phosphatase

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