Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5796
Official Symbol:PTPRK
Other Aliases:DKFZp686C2268|DKFZp779N1045|R-PTP-kappa
See related:HGNC:9674|MIM:602545|HPRD:03968
Chromosome:6
Location:6q22.2-23.1
Gene Description:protein tyrosine phosphatase, receptor type, K
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0964
ORGANISM:human
Entrez Gene ID:5796
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.5 :: -1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
19272CBCerebellum12.348123073577912.7493679523468
19272CTXCerebral cortex64.056653976440454.4406032562256
19272HIPHippocampal region30.298403739929243.1754169464111
19272HPFHippocampal formation42.363214492797953.3404350280762
19272HYHypothalamus13.098700523376510.565628528595
19272LSXLateral septal complex9.313838481903087.99143314361572
19272MBMidbrain12.903155803680412.0127034187317
19272MYMedulla12.429734706878712.3034801483154
19272OLFOlfactory bulb56.121774673461951.4493961334229
19272PPons9.673452854156499.09121179580688
19272PALPallidum8.273016929626467.03038454055786
19272RHPRetrohippocampal region58.862752914428763.966064453125
19272sAMYStriatum-like amygdalar nuclei9.625518321990976.74865508079529
19272STRStriatum4.94835972785954.39941835403442
19272STRdStriatum dorsal region3.630391001701353.41012501716614
19272STRvStriatum ventral region5.222991347312935.1459287405014
19272THThalamus6.343772888183596.47255730628967
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5796GO:0004725IEAFunctionprotein tyrosine phosphatase activity
5796GO:0004872IEAFunctionreceptor activity
5796GO:0005001TASFunctiontransmembrane receptor protein tyrosine phosphatase activity
5796GO:0005887TASComponentintegral to plasma membrane
5796GO:0006470IEAProcessprotein amino acid dephosphorylation
5796GO:0016020IEAComponentmembrane
5796GO:0016787IEAFunctionhydrolase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5796IPR003962FnIII_subdFibronectin, type III subdomain
5796IPR003961FN_IIIFibronectin, type III
5796IPR013098I-setImmunoglobulin I-set
5796IPR007110Ig-likeImmunoglobulin-like
5796IPR013151ImmunoglobulinImmunoglobulin
5796IPR000998MAMMAM
5796IPR000387TYR_phosphataseTyrosine specific protein phosphatase and dual specificity protein phosphatase
5796IPR000242Tyr_PPTyrosine specific protein phosphatase

© Center for Bioinformatics(CBI), Peking University
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