Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:581
Official Symbol:BAX
Other Aliases:Bax zeta
See related:HGNC:959|MIM:600040|HPRD:02498
Chromosome:19
Location:19q13.3-q13.4
Gene Description:BCL2-associated X protein
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0043
ORGANISM:human
Entrez Gene ID:581
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:10534122
Addiction Drug:OPIOIDS
Addiction Drug Detail:HEROIN ABUSE
Addiction Brain Area:Jurkat cells / T lymphocytes
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12028CBCerebellum27.817222595214841.4333305358887
12028CTXCerebral cortex88.561531066894572.9988327026367
12028HIPHippocampal region57.221427917480588.2930603027344
12028HPFHippocampal formation66.24536132812579.7969818115234
12028HYHypothalamus39.890674591064532.609676361084
12028LSXLateral septal complex25.610647201538117.7316150665283
12028MBMidbrain38.020366668701236.0068092346191
12028MYMedulla55.924106597900467.4604415893555
12028OLFOlfactory bulb63.006061553955152.2564544677734
12028PPons50.529014587402357.2681922912598
12028PALPallidum51.388149261474651.3252830505371
12028RHPRetrohippocampal region82.274780273437570.4988861083984
12028sAMYStriatum-like amygdalar nuclei69.167907714843859.2468948364258
12028STRStriatum46.307472229003935.3067207336426
12028STRdStriatum dorsal region43.795925140380933.209400177002
12028STRvStriatum ventral region51.540912628173836.6590728759766
12028THThalamus61.137668609619154.2355804443359
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
581GO:0005515IPIFunctionprotein binding
581GO:0005554NDFunctionmolecular function unknown
581GO:0006915IEAProcessapoptosis
581GO:0006917NASProcessinduction of apoptosis
581GO:0007049IEAProcesscell cycle
581GO:0007281TASProcessgerm cell development
581GO:0008372NDComponentcellular component unknown
581GO:0008624TASProcessinduction of apoptosis by extracellular signals
581GO:0008634TASProcessnegative regulation of survival gene product activity
581GO:0008637TASProcessapoptotic mitochondrial changes
581GO:0016020IEAComponentmembrane
581GO:0016021IEAComponentintegral to membrane
581GO:0042981IEAProcessregulation of apoptosis
581GO:0045786IEAProcessnegative regulation of progression through cell cycle
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-51100AAF81225.1Homo sapiens SH3-containing protein SH3GLB1 mRNA, complete cds.BIND209232
-1409NP_000385.1crystallin, alpha ABIND185555
-596NP_000624.1B-cell lymphoma protein 2 alpha isoformHPRD01045
-1410NP_001876.1crystallin, alpha BBIND185556
-597NP_004040.1BCL2-related protein A1HPRD03034
-10971NP_006817.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, theta polypeptideHPRD00886
-10017NP_065129.1BCL2-like 10 (apoptosis facilitator)HPRD06071
-64112NP_071434.2modulator of apoptosis 1BIND297456
-598NP_612815.1BCL2-like 1 isoform 1BIND196760
AY217036.17157NP_000537.2tumor protein p53BIND196729
NC_000019.87157NP_000537.2tumor protein p53BIND315954
NC_000019.87161NP_005418.1tumor protein p73BIND295555
NP_004315.1-AAK50430.1Homo sapiens Humanin (HN1) mRNA, complete cds.HPRD02498
NP_004315.1596-Bcl 2HPRD02498
NP_004315.1597-BCL2 related protein A1HPRD02498
NP_004315.110017-BCL2 like 10HPRD02498
NP_004315.110971-14-3-3 thetaHPRD02498
NP_004315.1596NP_000624.1B-cell lymphoma protein 2 alpha isoformHPRD01045
NP_004315.17416NP_003365.1voltage-dependent anion channel 1HPRD02498
NP_004315.17416NP_003365.1voltage-dependent anion channel 1HPRD05137
NP_004315.12810NP_006133.1stratifinHPRD02498
NP_004315.19774NP_055554.1BCL2-associated transcription factor 1HPRD16544
NP_004315.19774NP_055554.1BCL2-associated transcription factor 1HPRD02498
NP_004315.151100NP_057093.1SH3-containing protein SH3GLB1HPRD15333
NP_004315.151100NP_057093.1SH3-containing protein SH3GLB1HPRD02498
NP_004315.15366NP_066950.1phorbol-12-myristate-13-acetate-induced protein 1HPRD12002
NP_004315.15366NP_066950.1phorbol-12-myristate-13-acetate-induced protein 1HPRD02498
NP_004315.14170NP_068779.1myeloid cell leukemia sequence 1 isoform 1HPRD08870
NP_004315.164112NP_071434.2modulator of apoptosis 1HPRD17580
NP_004315.164112NP_071434.2modulator of apoptosis 1HPRD02498
NP_004315.1155807NP_057852.2Vpr--
NP_004315.1155807NP_057852.2Vpr--
NP_004315.1155807NP_057852.2Vpr--
NP_004315.1155871NP_057853.1Tat--
NP_004315.1155871NP_057853.1Tat--
NP_620116.1596--BIND193179
NP_620116.1596NP_000624.1B-cell lymphoma protein 2 alpha isoformBIND146452
NP_620116.1637NP_001187.1BH3 interacting domain death agonist isoform 2BIND193176
NP_620116.18996NP_003937.1nucleolar protein 3BIND182449
NP_620116.127113NP_055232.1BCL2 binding component 3BIND193181
NP_620116.164112NP_071434.2modulator of apoptosis 1BIND153632
NP_620116.1598NP_612815.1BCL2-like 1 isoform 1BIND153642
NP_620116.1598NP_612815.1BCL2-like 1 isoform 1BIND193180
U17193.16872--BIND215057
U17193.17157NP_000537.2tumor protein p53BIND215052
U17193.12959NP_001505.1general transcription factor IIBBIND215056
U17193.14582NP_002447.3mucin 1, transmembraneBIND215051
U17193.16908NP_003185.1TATA box binding proteinBIND215054
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
581IPR002475BCL2_apoptsisBCL2-like apoptosis inhibitor
581IPR000712Bcl2_BHApoptosis regulator Bcl-2, BH
581BAXA_HUMANQ07812IPR002475BCL2_apoptsisBCL2-like apoptosis inhibitor
581BAXA_HUMANQ07812IPR000712Bcl2_BHApoptosis regulator Bcl-2, BH
581BAXB_HUMANQ07814IPR002475BCL2_apoptsisBCL2-like apoptosis inhibitor
581BAXB_HUMANQ07814IPR000712Bcl2_BHApoptosis regulator Bcl-2, BH
581BAXD_HUMANP55269IPR002475BCL2_apoptsisBCL2-like apoptosis inhibitor
581BAXD_HUMANP55269IPR000712Bcl2_BHApoptosis regulator Bcl-2, BH

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.