Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5813
Official Symbol:PURA
Other Aliases:PUR-ALPHA|PUR1|PURALPHA
See related:HGNC:9701|MIM:600473|HPRD:02721
Chromosome:5
Location:5q31
Gene Description:purine-rich element binding protein A
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0191
ORGANISM:human
Entrez Gene ID:5813
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15312160
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Upregulated
Fold Change:-
KARG Evidence 2
KARG ID:EVIM0838
ORGANISM:human
Entrez Gene ID:5813
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:1 :: -1.9
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5813GO:0000784ICComponentnuclear chromosome, telomeric region
5813GO:0003677IEAFunctionDNA binding
5813GO:0003691IDAFunctiondouble-stranded telomeric DNA binding
5813GO:0003697ISSFunctionsingle-stranded DNA binding
5813GO:0003705TASFunctionRNA polymerase II transcription factor activity, enhancer binding
5813GO:0005634IDAComponentnucleus
5813GO:0005662ISSComponentDNA replication factor A complex
5813GO:0006268IDAProcessDNA unwinding during replication
5813GO:0006270TASProcessDNA replication initiation
5813GO:0006350IEAProcesstranscription
5813GO:0006355IEAProcessregulation of transcription, DNA-dependent
5813GO:0006915ISSProcessapoptosis
5813GO:0008134ISSFunctiontranscription factor binding
5813GO:0008283ISSProcesscell proliferation
5813GO:0030154ISSProcesscell differentiation
5813GO:0031575ISSProcessG1/S transition checkpoint
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5814NP_150093.1purine-rich element binding protein BHPRD12325
-6667NP_612482.2Sp1 transcription factorHPRD01796
NP_005850.1--MSY1HPRD02721
NP_005850.1--Pur-betaHPRD02721
NP_005850.16667-Transcription factor Sp1HPRD02721
NP_005850.111033NP_006860.1centaurin, alpha 1HPRD09733
NP_005850.11489517NP_043512.1hypothetical protein Jvgp5BIND19144
NP_005850.1155871NP_057853.1Tat--
NP_005850.1155871NP_057853.1Tat--
NP_005850.1155871NP_057853.1Tat--
NP_005850.1155871NP_057853.1Tat--
NP_005850.1155871NP_057853.1Tat--
NP_005850.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5813PUR_HUMANQ00577IPR006628PUR_DNA_RNA_bdPUR-alpha/beta/gamma, DNA/RNA-binding

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