Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5880
Official Symbol:RAC2
Other Aliases:EN-7|Gx|HSPC022
See related:HGNC:9802|MIM:602049|HPRD:03628
Chromosome:22
Location:22q13.1
Gene Description:ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0227
ORGANISM:human
Entrez Gene ID:5880
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Downregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5880GO:0000166IEAFunctionnucleotide binding
5880GO:0003924TASFunctionGTPase activity
5880GO:0005515IPIFunctionprotein binding
5880GO:0005525IEAFunctionGTP binding
5880GO:0005622IEAComponentintracellular
5880GO:0007165TASProcesssignal transduction
5880GO:0007264IEAProcesssmall GTPase mediated signal transduction
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-8454NP_003583.1cullin 1HPRD04389
NP_002863.18454-Cullin 1HPRD03628
NP_002863.110811NP_006638.1NADPH oxidase activator 1HPRD17644
NP_002863.123463NP_036537.1isoprenylcysteine carboxyl methyltransferaseHPRD09321
NP_002863.123463NP_036537.1isoprenylcysteine carboxyl methyltransferaseHPRD03628
NP_002863.150619NP_071330.2differentially expressed in FDCP 6 homologHPRD10869
NP_002863.150619NP_071330.2differentially expressed in FDCP 6 homologBIND182176
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5880RAC2_HUMANP15153IPR013684Miro-likeMiro-like
5880RAC2_HUMANP15153IPR013753RasRas
5880RAC2_HUMANP15153IPR001806Ras_trnsfrmngRas GTPase
5880RAC2_HUMANP15153IPR006036TrkA_KuptakeTrkA potassium uptake protein

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