Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5894
Official Symbol:RAF1
Other Aliases:CRAF|Raf-1|c-Raf
See related:HGNC:9829|MIM:164760|HPRD:01265
Chromosome:3
Location:3p25
Gene Description:v-raf-1 murine leukemia viral oncogene homolog 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0245
ORGANISM:human
Entrez Gene ID:5894
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15198681
Addiction Drug:OPIOINS
Addiction Drug Detail:Chronic opiate addiction, Downregulation
Addiction Brain Area:PFC
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
110157CBCerebellum15.594906330108617.9535574913025
110157CTXCerebral cortex2.173239767551421.37293842434883
110157HIPHippocampal region19.86035919189458.92844176292419
110157HPFHippocampal formation13.97441434860236.11278986930847
110157HYHypothalamus2.015504881739621.15610259771347
110157LSXLateral septal complex1.039883874356750.582307048141956
110157MBMidbrain3.289513528347022.56810683012009
110157MYMedulla8.105059623718267.10262537002563
110157OLFOlfactory bulb15.17005634307869.70637083053589
110157PPons8.982294678688057.40898835659027
110157PALPallidum1.927052840590481.37400920689106
110157RHPRetrohippocampal region4.363794207572942.36616039276123
110157sAMYStriatum-like amygdalar nuclei0.8663827180862430.496751084923744
110157STRStriatum1.087101057171820.535506553947926
110157STRdStriatum dorsal region0.5927571207284930.324195705354214
110157STRvStriatum ventral region3.466431796550751.39321718364954
110157THThalamus4.591637849807742.64509814977646
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5894GO:0000166IEAFunctionnucleotide binding
5894GO:0004674IEAFunctionprotein serine/threonine kinase activity
5894GO:0005057IEAFunctionreceptor signaling protein activity
5894GO:0005515IPIFunctionprotein binding
5894GO:0005524IEAFunctionATP binding
5894GO:0005741TASComponentmitochondrial outer membrane
5894GO:0006468TASProcessprotein amino acid phosphorylation
5894GO:0006915TASProcessapoptosis
5894GO:0007242IEAProcessintracellular signaling cascade
5894GO:0008270IEAFunctionzinc ion binding
5894GO:0008283TASProcesscell proliferation
5894GO:0016740IEAFunctiontransferase activity
5894GO:0019992IEAFunctiondiacylglycerol binding
5894GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-10256AAH11604.1CNKSR1 proteinHPRD11937
-7529NP_003395.1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideHPRD03184
-8837NP_003870.3CASP8 and FADD-like apoptosis regulatorHPRD04671
-6714NP_005408.1proto-oncogene tyrosine-protein kinase SRCHPRD01819
-7409NP_005419.2vav 1 oncogeneHPRD01284
-5934NP_005602.2retinoblastoma-like 2 (p130)HPRD01576
-6009NP_005605.1Ras homolog enriched in brainHPRD03188
-7531NP_006752.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptideHPRD05457
-22808NP_036351.2muscle RAS oncogene homologHPRD06662
-22800NP_036382.2related RAS viral (r-ras) oncogene homolog 2HPRD02518
-51765NP_057626.2serine/threonine protein kinase MASKHPRD06663
-81848NP_112226.2sprouty homolog 4HPRD10466
-283455NP_775869.2kinase suppressor of ras 2HPRD13952
NP_002871.1--Ras p21HPRD01265
NP_002871.1--GNG4HPRD01265
NP_002871.1--Tvl-1HPRD01265
NP_002871.1--MEKK1HPRD01265
NP_002871.1--Glucocorticoid receptorHPRD01265
NP_002871.1--JSAP1HPRD01265
NP_002871.1--Hsp90NHPRD01265
NP_002871.1--PRKG1HPRD01265
NP_002871.1--PP1CHPRD01265
NP_002871.1--GILZHPRD01265
NP_002871.1---BIND215344
NP_002871.1---BIND257755
NP_002871.16714-c-SrcHPRD01265
NP_002871.17531-14-3-3 epsilonHPRD01265
NP_002871.17529-14-3-3 BetaHPRD01265
NP_002871.17409-VAV1HPRD01265
NP_002871.16009-RAS homolog enriched in brain 2HPRD01265
NP_002871.15934-Retinoblastoma like 2HPRD01265
NP_002871.122800-R Ras2HPRD01265
NP_002871.122808-MRASHPRD01265
NP_002871.18837-c-FLIPHPRD01265
NP_002871.151765-MST4HPRD01265
NP_002871.15911AAH70031.1RAP2A, member of RAS oncogene familyBIND258811
NP_002871.15925NP_000312.1retinoblastoma 1HPRD01265
NP_002871.15925NP_000312.1retinoblastoma 1HPRD01574
NP_002871.15925NP_000312.1retinoblastoma 1BIND182520
NP_002871.192609NP_001001563.1translocase of inner mitochondrial membrane 50 homologBIND194883
NP_002871.192609NP_001001563.1translocase of inner mitochondrial membrane 50 homologBIND217454
NP_002871.15906NP_002875.1RAP1A, member of RAS oncogene familyHPRD01545
NP_002871.15906NP_002875.1RAP1A, member of RAS oncogene familyHPRD01265
NP_002871.17529NP_003395.1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideBIND193150
NP_002871.17529NP_003395.1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideBIND217453
NP_002871.17533NP_003396.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, eta polypeptideHPRD01265
NP_002871.17533NP_003396.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, eta polypeptideHPRD00215
NP_002871.17534NP_003397.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptideBIND12899
NP_002871.17534NP_003397.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptideHPRD01265
NP_002871.17534NP_003397.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptideHPRD03183
NP_002871.18533NP_003644.2COP9 constitutive photomorphogenic homolog subunit 3BIND194889
NP_002871.18533NP_003644.2COP9 constitutive photomorphogenic homolog subunit 3BIND217685
NP_002871.15934NP_005602.2retinoblastoma-like 2 (p130)BIND182659
NP_002871.16009NP_005605.1Ras homolog enriched in brainBIND295425
NP_002871.17203NP_005989.2chaperonin containing TCP1, subunit 3 (gamma)BIND182366
NP_002871.17203NP_005989.2chaperonin containing TCP1, subunit 3 (gamma)BIND217458
NP_002871.16788NP_006272.1serine/threonine kinase 3 (STE20 homolog, yeast)BIND182817
NP_002871.17531NP_006752.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptideBIND300600
NP_002871.111339NP_009211.1Opa interacting protein 5BIND182250
NP_002871.111339NP_009211.1Opa interacting protein 5BIND217456
NP_002871.18036NP_031399.1soc-2 suppressor of clear homologHPRD04144
NP_002871.18036NP_031399.1soc-2 suppressor of clear homologHPRD01265
NP_002871.122800NP_036382.2related RAS viral (r-ras) oncogene homolog 2BIND217683
NP_002871.17532NP_036611.2tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideHPRD01265
NP_002871.17532NP_036611.2tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideHPRD05639
NP_002871.123162NP_055948.1mitogen-activated protein kinase 8 interacting protein 3 isoform 1HPRD12014
NP_002871.123162NP_055948.1mitogen-activated protein kinase 8 interacting protein 3 isoform 1HPRD12014
NP_002871.151555NP_057643.1PXR2b proteinHPRD11425
NP_002871.151555NP_057643.1PXR2b proteinHPRD01265
NP_002871.155872NP_060962.2T-LAK cell-originated protein kinaseBIND217684
NP_002871.1157310NP_659399.1phosphatidylethanolamine-binding protein 4BIND216572
NP_002871.1256281NP_803877.2nudix -type motif 14BIND217686
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5894RAF1_HUMANP04049IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
5894RAF1_HUMANP04049IPR002219DAG_PE_bdProtein kinase C, phorbol ester/diacylglycerol binding
5894RAF1_HUMANP04049IPR000719Prot_kinaseProtein kinase
5894RAF1_HUMANP04049IPR003116Raf_like_ras_bdRaf-like Ras-binding
5894RAF1_HUMANP04049IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
5894RAF1_HUMANP04049IPR001245Tyr_pkinaseTyrosine protein kinase
5894RAF1_HUMANP04049IPR013695WAKWall-associated kinase

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