Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:590
Official Symbol:BCHE
Other Aliases:CHE1|E1
See related:HGNC:983|MIM:177400|HPRD:01519
Chromosome:3
Location:3q26.1-q26.2
Gene Description:butyrylcholinesterase
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIL0205
ORGANISM:human
Entrez Gene ID:590
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:16243302
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12038CBCerebellum1.178701609373091.43998050689697
12038CTXCerebral cortex1.067233234643940.926062405109406
12038HIPHippocampal region0.7056572064757350.607606656849384
12038HPFHippocampal formation1.310429826378821.04144408553839
12038HYHypothalamus0.5969051793217660.399461984634399
12038LSXLateral septal complex0.3044808581471440.24664181470871
12038MBMidbrain1.045558065176011.27796524763107
12038MYMedulla2.958190679550173.46104621887207
12038OLFOlfactory bulb2.142556369304662.46062129735947
12038PPons2.830587029457093.47407412528992
12038PALPallidum0.4868319332599640.483470156788826
12038RHPRetrohippocampal region2.848839223384862.02998979389668
12038sAMYStriatum-like amygdalar nuclei0.3602837473154070.299753904342651
12038STRStriatum0.6248593479394910.544700115919113
12038STRdStriatum dorsal region0.7055236548185350.529498241841793
12038STRvStriatum ventral region0.6966856122016910.669803529977798
12038THThalamus0.4998821914196010.411691326647997
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
590GO:0001540NASFunctionbeta-amyloid binding
590GO:0004104NASFunctioncholinesterase activity
590GO:0004759IEAFunctionserine esterase activity
590GO:0005576NASComponentextracellular region
590GO:0016787IEAFunctionhydrolase activity
590GO:0019899NASFunctionenzyme binding
590GO:0050783TASProcesscocaine metabolism
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-8292NP_005668.2acetylcholinesterase collagen-like tail subunit isoform I precursorHPRD04328
NP_000046.1---BIND209015
NP_000046.1---BIND209017
NP_000046.1---BIND209013
NP_000046.18292-Acetylcholinesterase collagenic tail peptideHPRD01519
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
590CHLE_HUMANP06276IPR002018CarbesteraseBCarboxylesterase, type B
590CHLE_HUMANP06276IPR000997CholinesteraseCholinesterase
590CHLE_HUMANP06276IPR000379Ser_estrsEsterase/lipase/thioesterase

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.