Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5901
Official Symbol:RAN
Other Aliases:ARA24|Gsp1|TC4
See related:HGNC:9846|MIM:601179|HPRD:03109
Chromosome:12
Location:12q24.3
Gene Description:RAN, member RAS oncogene family
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0866
ORGANISM:human
Entrez Gene ID:5901
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.4 :: 1.4
KARG Evidence 2
KARG ID:EVIM0890
ORGANISM:human
Entrez Gene ID:5901
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.4 :: 1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
75471CBCerebellum4.650124073028564.92463779449463
75471CTXCerebral cortex1.629871487617491.37560319900513
75471HIPHippocampal region2.063196897506712.19800090789795
75471HPFHippocampal formation1.481910109519961.52342879772186
75471HYHypothalamus0.5189491510391240.479753196239471
75471LSXLateral septal complex0.03790509700775150.0
75471MBMidbrain0.7228663563728330.873042345046997
75471MYMedulla7.660835266113288.60612869262695
75471OLFOlfactory bulb1.894701838493351.35540282726288
75471PPons1.776556730270392.29719853401184
75471PALPallidum0.6231205463409420.777868211269379
75471RHPRetrohippocampal region0.4472251534461980.561226785182953
75471sAMYStriatum-like amygdalar nuclei0.3545342385768890.328867375850677
75471STRStriatum0.4983815252780910.442039370536804
75471STRdStriatum dorsal region0.61010342836380.535697162151337
75471STRvStriatum ventral region0.3237043917179110.319542706012726
75471THThalamus0.3795064985752110.354848206043243
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5901GO:0000074NASProcessregulation of progression through cell cycle
5901GO:0000166IEAFunctionnucleotide binding
5901GO:0000178IEAComponentexosome (RNase complex)
5901GO:0000785IDAComponentchromatin
5901GO:0003682TASFunctionchromatin binding
5901GO:0003713NASFunctiontranscription coactivator activity
5901GO:0003924TASFunctionGTPase activity
5901GO:0005515IPIFunctionprotein binding
5901GO:0005525IDAFunctionGTP binding
5901GO:0005634IEAComponentnucleus
5901GO:0005643NASComponentnuclear pore
5901GO:0005737IDAComponentcytoplasm
5901GO:0006259TASProcessDNA metabolism
5901GO:0006405NASProcessRNA export from nucleus
5901GO:0006611NASProcessprotein export from nucleus
5901GO:0006886IEAProcessintracellular protein transport
5901GO:0007052TASProcessmitotic spindle organization and biogenesis
5901GO:0007165TASProcesssignal transduction
5901GO:0007264IEAProcesssmall GTPase mediated signal transduction
5901GO:0030521NASProcessandrogen receptor signaling pathway
5901GO:0045893NASProcesspositive regulation of transcription, DNA-dependent
5901GO:0050681NASFunctionandrogen receptor binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-8853NP_003878.1development- and differentiation-enhancing factor 2HPRD04820
-84220NP_005045.1RAN-binding protein 2-like 1 isoform 1HPRD04128
-10048NP_005484.1RAN binding protein 9HPRD04835
-10204NP_005787.1nuclear transport factor 2HPRD12050
-57510NP_065801.1exportin 5HPRD06385
-57610NP_065901.1RAN binding protein 10HPRD15207
NP_006316.1--p97HPRD03109
NP_006316.1--NTF2HPRD03109
NP_006316.1--Importin betaHPRD03109
NP_006316.1--Importin alphaHPRD03109
NP_006316.1--NXT1HPRD03109
NP_006316.1---BIND219802
NP_006316.110048-RAN binding protein 9HPRD03109
NP_006316.18853-PYK C terminus associated proteinHPRD03109
NP_006316.184220-RANBP2 alphaHPRD03109
NP_006316.157510-Exportin 5HPRD03109
NP_006316.15902NP_002873.1RAN binding protein 1HPRD03109
NP_006316.15902NP_002873.1RAN binding protein 1HPRD03110
NP_006316.15905NP_002874.1Ran GTPase activating protein 1HPRD03839
NP_006316.17514NP_003391.1exportin 1HPRD03975
NP_006316.17514NP_003391.1exportin 1HPRD03109
NP_006316.17046NP_004603.1transforming growth factor, beta receptor I precursorBIND218674
NP_006316.15903NP_006258.2RAN binding protein 2HPRD03109
NP_006316.15903NP_006258.2RAN binding protein 2HPRD03111
NP_006316.110527NP_006382.1importin 7HPRD03109
NP_006316.110527NP_006382.1importin 7HPRD09280
NP_006316.110762NP_009103.2nucleoporin 50kDa isoform bHPRD05226
NP_006316.111260NP_009166.2tRNA exportinHPRD03109
NP_006316.111260NP_009166.2tRNA exportinHPRD04418
NP_006316.18498NP_015561.1RAN binding protein 3 isoform RANBP3-dHPRD03109
NP_006316.18498NP_015561.1RAN binding protein 3 isoform RANBP3-dHPRD04508
NP_006316.151194NP_057422.3Ran binding protein 11HPRD10003
NP_006316.151194NP_057422.3Ran binding protein 11HPRD03109
NP_006316.129098NP_057576.1RAN guanine nucleotide release factorHPRD06407
NP_006316.129098NP_057576.1RAN guanine nucleotide release factorHPRD03109
NP_006316.191754NP_149107.3NIMA related kinase 9HPRD11386
NP_006316.1155908NP_057854.1Rev--
NP_006316.1155908NP_057854.1Rev--
NP_006316.1155908NP_057854.1Rev--
NP_006316.1155030NP_579876.2matrix--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5901RAN_HUMANP62826IPR006689ARF/SARARF/SAR superfamily
5901RAN_HUMANP62826IPR001019Gprotein_alph_bdGuanine nucleotide binding protein (G-protein), alpha subunit
5901RAN_HUMANP62826IPR013684Miro-likeMiro-like
5901RAN_HUMANP62826IPR002041RAN_GTP_bdGTP-binding nuclear protein Ran
5901RAN_HUMANP62826IPR013753RasRas
5901RAN_HUMANP62826IPR001806Ras_trnsfrmngRas GTPase

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