Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:59084
Official Symbol:ENPP5
Other Aliases:KIAA0879
See related:HGNC:13717|HPRD:13272
Chromosome:6
Location:6p21.1-p11.2
Gene Description:ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative function)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0053
ORGANISM:human
Entrez Gene ID:59084
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Upregulated
Fold Change:1.16 :: -0.69 :: -0.04 :: 0.94 :: 0.43 :: -0.16 :: 0.39 :: 0.42 :: 0.12 :: 0.30
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
83965CBCerebellum56.6992073059082100.0
83965CTXCerebral cortex100.0100.0
83965HIPHippocampal region100.0100.0
83965HPFHippocampal formation100.0100.0
83965HYHypothalamus100.0100.0
83965LSXLateral septal complex100.0100.0
83965MBMidbrain100.0100.0
83965MYMedulla100.0100.0
83965OLFOlfactory bulb100.0100.0
83965PPons100.0100.0
83965PALPallidum100.0100.0
83965RHPRetrohippocampal region100.0100.0
83965sAMYStriatum-like amygdalar nuclei100.0100.0
83965STRStriatum100.0100.0
83965STRdStriatum dorsal region100.0100.0
83965STRvStriatum ventral region100.0100.0
83965THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
59084GO:0009117IEAProcessnucleotide metabolism
59084GO:0016020IEAComponentmembrane
59084GO:0016021IEAComponentintegral to membrane
59084GO:0016787IEAFunctionhydrolase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
59084ENPP5_HUMANQ9UJA9IPR002591PhosphodiestType I phosphodiesterase/nucleotide pyrophosphatase

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