Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5925
Official Symbol:RB1
Other Aliases:OSRC|RB
See related:HGNC:9884|MIM:180200|HPRD:01574
Chromosome:13
Location:13q14.2
Gene Description:retinoblastoma 1 (including osteosarcoma)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0382
ORGANISM:human
Entrez Gene ID:5925
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24708
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:QTL0209
ORGANISM:human
Entrez Gene ID:5925
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
19645CBCerebellum27.456558227539138.2953681945801
19645CTXCerebral cortex68.20764923095755.8264656066895
19645HIPHippocampal region48.614055633544985.0342864990234
19645HPFHippocampal formation47.490245819091866.3402404785156
19645HYHypothalamus6.874928951263435.23616313934326
19645LSXLateral septal complex11.42453098297128.41024971008301
19645MBMidbrain20.261487960815418.5265007019043
19645MYMedulla11.176688194274910.8012866973877
19645OLFOlfactory bulb53.035423278808646.6811408996582
19645PPons12.864000320434612.8575439453125
19645PALPallidum6.086538791656494.95570135116577
19645RHPRetrohippocampal region44.67737579345739.0559120178223
19645sAMYStriatum-like amygdalar nuclei10.01803207397467.28947496414185
19645STRStriatum15.378222465515111.3104591369629
19645STRdStriatum dorsal region17.377346038818413.0903215408325
19645STRvStriatum ventral region13.57131958007819.1848087310791
19645THThalamus28.777242660522523.8020935058594
KARG Evidence 3
KARG ID:QTL0209
Trait:METH responses for climbing
Peak:41
Peak Marker:Es10
Parents:C57BL/6J x DBA/2J intercross
Evidence ID:8987796
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5925GO:0000075TASProcesscell cycle checkpoint
5925GO:0000122TASProcessnegative regulation of transcription from RNA polymerase II promoter
5925GO:0000279NASProcessM phase
5925GO:0000785TASComponentchromatin
5925GO:0003700TASFunctiontranscription factor activity
5925GO:0003713NASFunctiontranscription coactivator activity
5925GO:0005515IPIFunctionprotein binding
5925GO:0005554NDFunctionmolecular function unknown
5925GO:0005634NASComponentnucleus
5925GO:0005634TASComponentnucleus
5925GO:0006350IEAProcesstranscription
5925GO:0006355NASProcessregulation of transcription, DNA-dependent
5925GO:0006469IPIProcessnegative regulation of protein kinase activity
5925GO:0030308TASProcessnegative regulation of cell growth
5925GO:0030521NASProcessandrogen receptor signaling pathway
5925GO:0045786IEAProcessnegative regulation of progression through cell cycle
5925GO:0045893NASProcesspositive regulation of transcription, DNA-dependent
5925GO:0050681NASFunctionandrogen receptor binding
5925GO:0051318TASProcessG1 phase
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5932AAH30590.1RBBP8 proteinHPRD04990
-5931NP_002884.1retinoblastoma binding protein 7HPRD04231
-6015NP_002922.1ring finger protein 1HPRD03624
-6597NP_003063.2SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4HPRD04459
-6598NP_003064.2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 isoform aHPRD03364
-6670NP_003102.1Sp3 transcription factor isoform 1HPRD03483
-8503NP_003620.1phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma)HPRD05831
-8535NP_003646.1chromobox homolog 4HPRD04357
-8575NP_003681.1protein kinase, interferon-inducible double stranded RNA dependent activatorHPRD04573
-8900NP_003905.1cyclin A1HPRD04946
-5929NP_005048.1retinoblastoma binding protein 5HPRD02826
-9984NP_005122.1nuclear matrix protein p84HPRD09498
-5928NP_005601.1retinoblastoma binding protein 4HPRD04232
-10741NP_006597.2retinoblastoma binding protein 9HPRD04217
-7799NP_036363.2retinoblastoma protein-binding zinc finger protein isoform aHPRD03120
-26959NP_036389.2HMG-box transcription factor 1HPRD13634
-9643NP_036418.1MORF-related gene XHPRD02326
-7343NP_055048.1upstream binding transcription factor, RNA polymerase IHPRD02814
-23741NP_055150.1CREBBP/EP300 inhibitor 1HPRD06907
-286826NP_775106.2lin-9 homologHPRD13990
-6689Q01892Transcription factor Spi-B.HPRD06007
NP_000312.1---BIND217622
NP_000312.1---BIND259578
NP_000312.1--MCM7HPRD01574
NP_000312.1---BIND197429
NP_000312.1---BIND197430
NP_000312.1---BIND197431
NP_000312.1--DNMT1HPRD01574
NP_000312.1---BIND130522
NP_000312.15928-Retinoblastoma binding protein 4HPRD01574
NP_000312.15931-Retinoblastoma binding protein 7HPRD01574
NP_000312.19984-THO complex, subunit 1HPRD01574
NP_000312.17799-PR domain containing protein 2HPRD01574
NP_000312.15929-Retinoblastoma binding protein 5HPRD01574
NP_000312.16670-Transcription factor Sp3HPRD01574
NP_000312.16597-SMARCA4HPRD01574
NP_000312.18575-PKR protein activatorHPRD01574
NP_000312.110741-Retinoblastoma binding protein 9HPRD01574
NP_000312.15932-CTIPHPRD01574
NP_000312.18900-Cyclin A1HPRD01574
NP_000312.16689-SPIB transcription factorHPRD01574
NP_000312.17343-Upstream binding factorHPRD01574
NP_000312.123741-EID1HPRD01574
NP_000312.16598-SMARCB1HPRD01574
NP_000312.16015-Ring Finger Protein 1HPRD01574
NP_000312.18535-PC2HPRD01574
NP_000312.18503-Phosphatidylinositol 3 kinase, regulatory gamma subunitHPRD01574
NP_000312.19643-Mortality factor 4 like 2HPRD01574
NP_000312.16502--BIND182279
NP_000312.17329--BIND295900
NP_000312.127043AAC17708.2Human p160 mRNA, and translated productsBIND183279
NP_000312.126574AAD52016.1Homo sapiens Che-1 mRNA, complete cds.BIND133319
NP_000312.1286826AAH65302.1LIN9 proteinBIND182570
NP_000312.17422AF095785.1Homo sapiens vascular endothelial growth factor (VEGF) gene, promoter region and partial cdsBIND216592
NP_000312.154796BAA90908.1unnamed protein productBIND300805
NP_000312.110902NC_000005.8Homo sapiens chromosome 5, reference assemblyBIND300811
NP_000312.16046NC_000006.9Homo sapiens chromosome 6BIND300812
NP_000312.17299NC_000011.8Homo sapiens chromosome 11, reference assemblyBIND214951
NP_000312.15933NC_000011.8Homo sapiens chromosome 11, reference assemblyBIND214950
NP_000312.15925NP_000312.1retinoblastoma 1HPRD01574
NP_000312.17704NP_001018011.1promyelocytic leukemia zinc finger proteinBIND300806
NP_000312.15926NP_002883.2retinoblastoma-binding protein 1 isoform IHPRD01575
NP_000312.15926NP_002883.2retinoblastoma-binding protein 1 isoform IHPRD01574
NP_000312.15931NP_002884.1retinoblastoma binding protein 7BIND12645
NP_000312.16617NP_003073.1small nuclear RNA activating complex, polypeptide 1, 43kDaBIND54405
NP_000312.16619NP_003075.1small nuclear RNA activating complex, polypeptide 3, 50kDaHPRD01574
NP_000312.16619NP_003075.1small nuclear RNA activating complex, polypeptide 3, 50kDaHPRD03826
NP_000312.16619NP_003075.1small nuclear RNA activating complex, polypeptide 3, 50kDaBIND54407
NP_000312.16839NP_003164.1suppressor of variegation 3-9 homolog 1HPRD02221
NP_000312.16839NP_003164.1suppressor of variegation 3-9 homolog 1HPRD01574
NP_000312.16908NP_003185.1TATA box binding proteinBIND54410
NP_000312.17112NP_003267.1thymopoietin isoform alphaHPRD01777
NP_000312.17112NP_003267.1thymopoietin isoform alphaHPRD01574
NP_000312.17112NP_003267.1thymopoietin isoform alphaBIND54446
NP_000312.18503NP_003620.1phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma)BIND54373
NP_000312.18507NP_003624.1ectodermal-neural cortex (with BTB-like domain)HPRD05529
NP_000312.18507NP_003624.1ectodermal-neural cortex (with BTB-like domain)HPRD01574
NP_000312.18804NP_003842.1cellular repressor of E1A-stimulated genesHPRD01574
NP_000312.18804NP_003842.1cellular repressor of E1A-stimulated genesHPRD09897
NP_000312.18841NP_003874.2histone deacetylase 3HPRD01574
NP_000312.18850NP_003875.3p300/CBP-associated factorBIND145156
NP_000312.19321NP_004230.1thyroid hormone receptor interactor 11HPRD01574
NP_000312.19321NP_004230.1thyroid hormone receptor interactor 11HPRD05143
NP_000312.16872NP_004597.2TBP-associated factor 1 isoform 1HPRD02436
NP_000312.16872NP_004597.2TBP-associated factor 1 isoform 1HPRD01574
NP_000312.17052NP_004604.1transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)HPRD01825
NP_000312.17052NP_004604.1transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)HPRD01574
NP_000312.15927NP_005047.1retinoblastoma binding protein 2HPRD08915
NP_000312.15927NP_005047.1retinoblastoma binding protein 2BIND134412
NP_000312.15927NP_005047.1retinoblastoma binding protein 2BIND300807
NP_000312.15928NP_005601.1retinoblastoma binding protein 4BIND12646
NP_000312.110399NP_006089.1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1HPRD01574
NP_000312.110399NP_006089.1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1BIND54422
NP_000312.110403NP_006092.1kinetochore associated 2HPRD01574
NP_000312.110403NP_006092.1kinetochore associated 2HPRD06277
NP_000312.110620NP_006456.1AT rich interactive domain 3B (BRIGHT- like) proteinHPRD09806
NP_000312.110620NP_006456.1AT rich interactive domain 3B (BRIGHT- like) proteinHPRD01574
NP_000312.126574NP_036270.1apoptosis antagonizing transcription factorHPRD12236
NP_000312.123054NP_054790.2nuclear receptor coactivator 6BIND180477
NP_000312.123741NP_055150.1CREBBP/EP300 inhibitor 1BIND295898
NP_000312.123741NP_055150.1CREBBP/EP300 inhibitor 1BIND300860
NP_000312.127043NP_055204.1proline-, glutamic acid-, leucine-rich protein 1HPRD10144
NP_000312.127043NP_055204.1proline-, glutamic acid-, leucine-rich protein 1HPRD01574
NP_000312.110131NP_057376.1TNF receptor-associated protein 1HPRD01574
NP_000312.110131NP_057376.1TNF receptor-associated protein 1HPRD05868
NP_000312.155814NP_060899.1transcription factor-like nuclear regulatorBIND54369
NP_000312.155957NP_061977.1hypothetical protein LOC55957BIND182568
NP_000312.157786NP_066986.1RB-associated KRAB repressorHPRD16296
NP_000312.16667NP_612482.2Sp1 transcription factorHPRD01796
NP_000312.16667NP_612482.2Sp1 transcription factorHPRD01574
NP_000312.16872NP_620278.1TBP-associated factor 1 isoform 2BIND130451
NP_000312.1132660NP_919258.1hypothetical protein LOC132660BIND182569
NP_000312.110933NP_996670.1MORF-related gene 15 isoform 2HPRD01574
NP_000312.110933NP_996670.1MORF-related gene 15 isoform 2HPRD09532
NP_000312.11487821NP_783796.1IE2BIND149074
NP_000312.11489531NP_043127.1large T antigenBIND300862
NP_000312.1155871NP_057853.1Tat--
NP_000312.1155871NP_057853.1Tat--
NP_000312.1155871NP_057853.1Tat--
NP_000312.12652980--BIND295896
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5925RB_HUMANP06400IPR000694PRO_richProline-rich region
5925RB_HUMANP06400IPR002720RB_ARetinoblastoma-associated protein, A-box
5925RB_HUMANP06400IPR002719RB_BRetinoblastoma-associated protein, B-box

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