Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:595
Official Symbol:CCND1
Other Aliases:BCL1|D11S287E|PRAD1|U21B31
See related:HGNC:1582|MIM:168461|HPRD:01346
Chromosome:11
Location:11q13
Gene Description:cyclin D1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0404
ORGANISM:human
Entrez Gene ID:595
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.6 :: -1.6 :: -1.5 :: -1.7 :: -2.1 :: -2.2
KARG Evidence 2
KARG ID:EVIM0472
ORGANISM:human
Entrez Gene ID:595
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.1 :: -1.2 :: -1.3 :: -5 :: -1.5
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
12443CBCerebellum100.0100.0
12443CTXCerebral cortex100.0100.0
12443HIPHippocampal region100.0100.0
12443HPFHippocampal formation100.0100.0
12443HYHypothalamus68.631881713867257.6418495178223
12443LSXLateral septal complex100.0100.0
12443MBMidbrain79.145942687988376.0749740600586
12443MYMedulla51.892482757568454.8210868835449
12443OLFOlfactory bulb100.0100.0
12443PPons45.822635650634845.8247184753418
12443PALPallidum64.307624816894561.8994140625
12443RHPRetrohippocampal region100.0100.0
12443sAMYStriatum-like amygdalar nuclei100.0100.0
12443STRStriatum100.0100.0
12443STRdStriatum dorsal region100.0100.0
12443STRvStriatum ventral region100.089.7628479003906
12443THThalamus67.301277160644561.7113800048828
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
595GO:0000074IEAProcessregulation of progression through cell cycle
595GO:0000082NASProcessG1/S transition of mitotic cell cycle
595GO:0005515IPIFunctionprotein binding
595GO:0005634IEAComponentnucleus
595GO:0007049IEAProcesscell cycle
595GO:0008372NDComponentcellular component unknown
595GO:0051301IEAProcesscell division
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-1019NP_000066.1cyclin-dependent kinase 4HPRD00447
-2099NP_000116.1estrogen receptor 1HPRD00589
-5925NP_000312.1retinoblastoma 1HPRD01574
-2033NP_001420.1E1A binding protein p300HPRD04078
-4605NP_002457.1MYB-related protein BHPRD03247
-7067NP_003241.2thyroid hormone receptor, alpha isoform 2HPRD07185
-8648NP_003734.3nuclear receptor coactivator 1 isoform 1HPRD04070
-8850NP_003875.3p300/CBP-associated factorHPRD06780
-3429NP_005523.1interferon, alpha-inducible protein 27HPRD02479
-10270NP_005849.1A-kinase anchor protein 8HPRD05258
-8202NP_006525.1nuclear receptor coactivator 3HPRD03570
-801NP_008819.1calmodulin 1HPRD00241
-672NP_009225.1breast cancer 1, early onset isoform 1HPRD00218
-23582NP_036274.2cyclin D-type binding-protein 1 isoform 1HPRD06156
-9978NP_055063.1ring-box 1HPRD06794
-51191NP_057407.1hect domain and RLD 5HPRD10502
-9988NP_066968.1cyclin D binding myb-like transcription factor 1HPRD09770
-1026NP_510867.1cyclin-dependent kinase inhibitor 1AHPRD00298
-6774NP_644805.1signal transducer and activator of transcription 3 isoform 1HPRD00026
NC_000011.88202--BIND259363
NC_000011.82071NP_000113.1excision repair cross-complementing rodent repair deficiency, complementation group 3BIND295493
NC_000011.82099NP_000116.1estrogen receptor 1BIND259362
NC_000011.85430NP_000928.1DNA directed RNA polymerase II polypeptide ABIND259364
NC_000011.81147NP_001269.3conserved helix-loop-helix ubiquitous kinaseBIND259366
NC_000011.81499NP_001895.1catenin (cadherin-associated protein), beta 1, 88kDaBIND197194
NC_000011.81387NP_004371.1CREB binding proteinBIND259365
NC_000011.85970NP_068810.2v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65BIND199759
NP_444284.11019NP_000066.1cyclin-dependent kinase 4BIND223918
NP_444284.11019NP_000066.1cyclin-dependent kinase 4BIND54874
NP_444284.15925NP_000312.1retinoblastoma 1BIND130450
NP_444284.11026NP_000380.1cyclin-dependent kinase inhibitor 1ABIND258438
NP_444284.11026NP_000380.1cyclin-dependent kinase inhibitor 1ABIND295916
NP_444284.11026NP_000380.1cyclin-dependent kinase inhibitor 1ABIND197217
NP_444284.11021NP_001250.1cyclin-dependent kinase 6HPRD04533
NP_444284.11021NP_001250.1cyclin-dependent kinase 6BIND218052
NP_444284.11316NP_001291.3Kruppel-like factor 6BIND144528
NP_444284.11032NP_001791.1cyclin-dependent kinase inhibitor 2DHPRD02957
NP_444284.11499NP_001895.1catenin (cadherin-associated protein), beta 1, 88kDaHPRD00286
NP_444284.15933NP_002886.2retinoblastoma-like protein 1 isoform aHPRD00312
NP_444284.15981NP_002904.3replication factor C large subunitHPRD00024
NP_444284.18452NP_003581.1cullin 3HPRD09123
NP_444284.11027NP_004055.1cyclin-dependent kinase inhibitor 1BHPRD02867
NP_444284.11027NP_004055.1cyclin-dependent kinase inhibitor 1BBIND197221
NP_444284.16872NP_004597.2TBP-associated factor 1 isoform 1HPRD02436
NP_444284.16872NP_004597.2TBP-associated factor 1 isoform 1HPRD02436
NP_444284.15300NP_006212.1protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1BIND214287
NP_444284.1672NP_009227.1breast cancer 1, early onset isoform 1BIND12635
NP_444284.156654NP_056207.2neural proliferation, differentiation and control, 1HPRD12048
NP_444284.16872NP_620278.1TBP-associated factor 1 isoform 2BIND130449
NP_444284.155388NP_877428.1minichromosome maintenance protein 10 isoform 1HPRD11297
NP_444284.1155871NP_057853.1Tat--
NT_035113.64303NP_005929.1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)BIND217705
Z29078.11385--BIND315939
Z29078.11956--BIND300538
Z29078.16774--BIND300544
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
595CCND1_HUMANP24385IPR004367Cyclin_CCyclin, C-terminal
595CCND1_HUMANP24385IPR006671Cyclin_NCyclin, N-terminal

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